Fecal lactoferrin and calprotectin after ileocolonic resection for Crohn's disease
Fecal lactoferrin and calprotectin after ileocolonic resection for Crohn's disease
复制标题
DOI：
10.1007/s10350-007-0225-6
复制
发表时间：
2007-06-01
影响因子：
3.9
通讯作者：
Angriman, Imerio
中科院分区：
文献类型：
--
作者：
Scarpa, Marco;D'Inca, Renata;Angriman, Imerio
目得：本研究旨在评估粪便乳铁蛋白和钙卫蛋白作为克罗恩病患者接受回结肠切除术后肠道炎症标志物的作用。方法：63例因克罗恩病接受回结肠切除术的患者入组，中位随访时间为40.5（范围，5-102）个月。进行临床检查和血液检查，并测定粪便乳铁蛋白和钙卫蛋白水平。在单变量分析中显著的粪便乳铁蛋白和钙卫蛋白水平的预测因子包括在两个多元回归分析模型中。结果：平均乳铁蛋白水平为21 +/- 3.9 μ g/g，平均钙卫蛋白粪便水平为247 +/- 22.7 ng/ml。C-反应蛋白水平（P < 0.01）、钙卫蛋白水平（P < 0.01）和临床复发（P = 0.04）是乳铁蛋白水平的独立预测因子。只有乳铁蛋白水平是粪便钙卫蛋白水平的独立预测因子（P < 0.01）。结论：克罗恩病患者在切除病变肠后的长期随访中，即使在临床缓解的情况下，仍保持高的乳铁蛋白和钙卫蛋白粪便水平。两种粪便标志物之间的显著相关性可能是正在进行的肠道炎症的表达。只有乳铁蛋白与C反应蛋白显著相关，并显示出系统性炎症的可靠阈值。粪便乳铁蛋白水平可能是肠道炎症影响全身炎症状态的可靠指标。粪便乳铁蛋白水平的第三个预测因素是术后随访期间临床复发事件的存在。
PURPOSE: This study was designed to assess the role of fecal lactoferrin and calprotectin as markers of intestinal inflammation in patients with Crohn's disease who have undergone ileocolonic resection. METHODS: Sixty-three patients who had undergone ileocolonic resection for Crohn's disease with a median follow-up of 40.5 (range, 5-102) months were enrolled. Clinical examination and blood test were performed, and fecal lactoferrin and calprotectin levels were dosed. The predictors for fecal lactoferrin and calprotectin levels that resulted to be significant at the univariate analyses were included in two multiple regression analysis models. RESULTS: The mean lactoferrin level was 21 +/- 3.9 mu g/g and the mean calprotectin fecal level was 247 +/- 22.7 ng/ml. C-reactive protein levels (P < 0.01), calprotectin levels (P < 0.01), and the presence of clinical recurrence (P = 0.04) resulted to be independent predictors of lactoferrin levels. Only lactoferrin levels resulted to be an independent predictor for calprotectin fecal levels (P < 0.01). CONCLUSIONS: Crohn's disease patients maintain high fecal levels of lactoferrin and calprotectin at long-term follow-up after resection of the diseased bowel even in case of clinical remission. The significant correlation between the two fecal markers may be the expression of the ongoing intestinal inflammation. Only lactoferrin significantly correlated with C-reactive protein and showed a reliable threshold value for systemic inflammation. Lactoferrin fecal levels may be a reliable indicator for intestinal inflammation influencing the systemic inflammatory status. The third predictor of lactoferrin fecal level was the presence of episodes of clinical recurrence during the postoperative follow-up.