THE RELATION BETWEEN INSULIN SENSITIVITY AND THE FATTY-ACID COMPOSITION OF SKELETAL-MUSCLE PHOSPHOLIPIDS
THE RELATION BETWEEN INSULIN SENSITIVITY AND THE FATTY-ACID COMPOSITION OF SKELETAL-MUSCLE PHOSPHOLIPIDS
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DOI：
10.1056/nejm199301283280404
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发表时间：
1993-01-28
影响因子：
158.5
通讯作者：
CAMPBELL, LV
中科院分区：
文献类型：
--
作者：
BORKMAN, M;STORLIEN, LH;CAMPBELL, LV
背景资料。胰岛素抵抗和高胰岛素血症是肥胖、非胰岛素依赖型糖尿病和其他疾病的特征。骨骼肌是胰岛素作用的主要部位，胰岛素敏感性可能与参与胰岛素作用的肌膜内磷脂的脂肪酸组成有关。我们确定了两组受试者骨骼肌磷脂的脂肪酸组成与胰岛素敏感性之间的关系。在一项研究中，我们从27名接受冠状动脉手术的患者身上获取了腹直肌样本；空腹血清胰岛素水平提供了胰岛素敏感性的指标。在第二项研究中，对13名正常男性的股外侧肌进行了活组织检查，并通过正常血糖钳夹研究评估了胰岛素敏感性。在手术患者中，空腹血清胰岛素浓度(衡量胰岛素抵抗的一种指标)与肌肉磷脂部分中单个长链多不饱和脂肪酸的百分比呈负相关，尤其是花生四烯酸(r=-0.63，P
Background. Insulin resistance and hyperinsulinemia are features of obesity, non-insulin-dependent diabetes mellitus, and other disorders. Skeletal muscle is a major site of insulin action, and insulin sensitivity may be related to the fatty-acid composition of the phospholipids within the muscle membranes involved in the action of insulin.Methods. We determined the relation between the fatty-acid composition of skeletal-muscle phospholipids and insulin sensitivity in two groups of subjects. In one study, we obtained samples of the rectus abdominis muscle from 27 patients undergoing coronary artery surgery; fasting serum insulin levels provided an index of insulin sensitivity. In the second study, a biopsy of the vastus lateralis muscle was performed in 13 normal men, and insulin sensitivity was assessed by euglycemic-clamp studies.Results. In the patients undergoing surgery, the fasting serum insulin concentration (a measure of insulin resistance) was negatively correlated with the percentage of individual long-chain polyunsaturated fatty acids in the phospholipid fraction of muscle, particularly arachidonic acid (r = -0.63, P