A nickel-catalyzed route to pyridines
A nickel-catalyzed route to pyridines
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DOI：
10.1021/ja0508931
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发表时间：
2005-04-13
影响因子：
15
通讯作者：
Louie, J
中科院分区：
文献类型：
--
作者：
McCormick, MM;Duong, HA;Louie, J
介绍了从腈和炔制备吡啶的一种温和而通用的方法。采用镍/咪唑烷配合物在常温下催化环化炔和芳基腈和烷基腈。此外，该方案的有效性允许制备融合的七元吡啶酮和分子间环化。当采用不对称的嘧啶时，环化产生单一的吡啶区域异构体。
A mild and general route for preparing pyridines from nitriles and diynes is described. Ni/imidazolyidene complexes were used to mediate cyclization alkynes and both aryl and alkyl nitriles at ambient temperature. In addition, the efficacy of this protocol allows for the preparation of a fused seven-membered pyridone and for intermolecular cyclizations. When an asymmetrical diyne was employed, cyclization afforded a single pyridine regioisomer.