Cerebral venous thrombosis, pregnancy and oral contraceptives
Cerebral venous thrombosis, pregnancy and oral contraceptives
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DOI：
10.1016/j.thromres.2012.08.264
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发表时间：
2012-10-01
影响因子：
7.5
通讯作者：
Crassard, Isabelle
中科院分区：
文献类型：
--
作者：
Bousser, Marie-Germaine;Crassard, Isabelle
脑静脉血栓形成(CVT)是一种罕见的脑血管疾病，占卒中总数的0.5%。它可能发生在任何年龄。它有3/1的女性优势，在年轻女性中达到高峰，这是由于性别特有的危险因素，特别是口服避孕药，其次是怀孕、产后和体外受精。尽管临床表现多种多样，但早期诊断(主要是基于MRI/MRA)是至关重要的，但往往很困难，特别是在产后，因为分娩后可能发生头痛的原因很多。应尽快开始以低分子肝素为基础的抗血栓治疗和对症治疗。CVT的总体预后远好于动脉卒中，在有性别特定危险因素的女性中甚至更好，80%的患者完全康复。未来怀孕不是禁忌，但用发情-孕激素避孕肯定是禁忌。(C)2012爱思唯尔有限公司。保留所有权利。
Cerebral venous thrombosis (CVT) is a rare variety of cerebro-vascular disease accounting for 0.5% of all stroke. It can occur at any age. It has a 3/1 female preponderance with a peak in young women due to gender specific risk factors, especially oral contraceptives and to lesser extent pregnancy, post-partum, and in vitro fertilization. Despite a wide variety of clinical presentations, early diagnosis, mostly based on MRI/MRA, is crucial but often difficult particularly during post-partum because of the numerous causes of headache that may occur after delivery. Antitrombotic treatment based on low molecular weight heparin and symptomatic treatment should be started as rapidly as possible. The overall prognosis of CVT is much better than that of arterial stroke and it is even better in women with gender specific risk factors, with a complete recovery in 80% of patients. Future pregnancy is not contra-indicated, but contraception with oestro-progestogens is definitely contra-indicated. (C) 2012 Elsevier Ltd. All rights reserved.