SURFACE ANTIGENS COMMON TO MOUSE CLEAVAGE EMBRYOS AND PRIMITIVE TERATOCARCINOMA CELLS IN CULTURE
SURFACE ANTIGENS COMMON TO MOUSE CLEAVAGE EMBRYOS AND PRIMITIVE TERATOCARCINOMA CELLS IN CULTURE
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DOI：
10.1073/pnas.70.10.2988
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发表时间：
1973-01-01
影响因子：
11.1
通讯作者：
JACOB, F
中科院分区：
文献类型：
--
作者：
ARTZT, K;DUBOIS, P;JACOB, F
已在小鼠品系129/Sv-CP雄性中产生抗畸胎癌原始细胞的同基因抗血清。这些血清与原始细胞特异性反应，并且对来自同一原始肿瘤的各种类型的分化畸胎瘤细胞呈阴性。除雄性生殖细胞和卵裂期胚胎外，它们对所有其他检测的小鼠细胞均呈阴性。因此，畸胎瘤细胞具有与正常卵裂期胚胎相同的细胞表面抗原。
Syngeneic antisera have been produced in mouse strain 129/Sv-CP males against the primitive cells of teratocarcinoma. These sera react specifically with the primitive cells and are negative on various types of differentiated teratoma cells derived from the same original tumor. They are negative on all other mouse cells tested, with the exception of male germ cells and cleavage-stage embryos. Thus, teratoma cells possess cell-surface antigens in common with normal cleavage-stage embryos.