Faecal virome of cats in an animal shelter
Faecal virome of cats in an animal shelter
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DOI：
10.1099/vir.0.069674-0
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发表时间：
2014-11-01
影响因子：
3.8
通讯作者：
Delwart, Eric
中科院分区：
文献类型：
--
作者：
Zhang, Wen;Li, Linlin;Delwart, Eric
我们描述了来自加州一个收容所的25只猫粪便中的宏基因组学来源的猫肠道病毒组。超过90%的可识别病毒读段与哺乳动物病毒相关，其余与细菌病毒相关。共检测到8个病毒科：星状病毒科、冠状病毒科、细小病毒科、圆环病毒科、疱疹病毒科、环状病毒科、杯状病毒科和Picobirnaviridae。还鉴定了六种以前已知的病毒：猫冠状病毒1型、猫疱疹1型、猫杯状病毒、猫诺如病毒、猫泛白细胞减少症病毒和皮考贝纳病毒。星状病毒和博卡病毒的新物种，以及猫中环状病毒的第一个基因组的特征。对来自小核糖核酸病毒目中四种高度不同的部分病毒基因组的RNA依赖性RNA聚合酶区域进行测序。在一个庇护所内检测到如此多样化的病毒，表明这些动物经历了强大的病毒暴露。这项研究增加了我们对猫的病毒多样性的理解，有利于未来对其致病性和人畜共患病潜力的评估。
We describe the metagenomics-derived feline enteric virome in the faeces of 25 cats from a single shelter in California. More than 90% of the recognizable viral reads were related to mammalian viruses and the rest to bacterial viruses. Eight viral families were detected: Astroviridae, Coronaviridae, Parvoviridae, Circoviridae, Herpesviridae, Anelloviridae, Caliciviridae and Picobirnaviridae. Six previously known viruses were also identified: feline coronavirus type 1, felid herpes 1, feline calicivirus, feline norovirus, feline panleukopenia virus and picobirnavirus. Novel species of astroviruses and bocaviruses, and the first genome of a cyclovirus in a feline were characterized. The RNA-dependent RNA polymerase region from four highly divergent partial viral genomes in the order Picornavirales were sequenced. The detection of such a diverse collection of viruses shed within a single shelter suggested that such animals experience robust viral exposures. This study increases our understanding of the viral diversity in cats, facilitating future evaluation of their pathogenic and zoonotic potentials.