Metabolic Syndrome and All-Cause and Cardiovascular Disease Mortality - Japan Public Health Center-Based Prospective (JPHC) Study
Metabolic Syndrome and All-Cause and Cardiovascular Disease Mortality - Japan Public Health Center-Based Prospective (JPHC) Study
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DOI：
10.1253/circj.cj-08-1025
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发表时间：
2009-05-01
影响因子：
3.3
通讯作者：
Tsugane, Shoichiro
中科院分区：
文献类型：
--
作者：
Saito, Isao;Iso, Hiroyasu;Tsugane, Shoichiro
背景资料：虽然代谢综合征（MetS）被认为主要是由内脏脂肪堆积引起的，但缺乏流行病学证据表明肥胖是否是代谢综合征的一个重要因素。在1990年至2005年期间，日本公共卫生中心的前瞻性（JPHC）研究对12,412名男性和21名女性进行了代谢危险因素的基线测量，639名女性，年龄40-69岁，无心血管疾病（CVD）或癌症病史。为了阐明肥胖的作用，日本MetS的定义已被采纳为一个基本标准，根据超重状况分组的数据中的危险因素的聚类进行了检查。在12.3年的随访中，有2,040人死亡。包括947例癌症和304例心血管疾病。MetS显著增加了女性全因死亡率和男性CVD死亡率的风险比。非超重且有≥ 2个危险因素的患者对全因死亡率和心血管疾病死亡率的影响相似。代谢因素的聚集导致死亡率的风险比线性增加。结论：代谢综合征导致全因和心血管疾病死亡率中度增加。然而，要求肥胖的MetS定义可能不一定识别具有高死亡风险并且比MetS受试者更普遍的非超重个体。(Circ J 2009; 73：878-884）
Background: Although the metabolic syndrome (MetS) is considered to be caused primarily by visceral fat accumulation, epidemiological evidence is lacking as to whether or not obesity is an essential element in the syndrome.Methods and Results: Between 1990 and 2005, the Japan Public Health Center-based Prospective (JPHC) Study conducted baseline measurements of metabolic risk factors in 12,412 men and 21,639 women, aged 40-69 years, with no history of cardiovascular disease (CVD) or cancer. To clarify the role of obesity, which the definition of MetS in Japan has adopted as an essential criterion, clustering of risk factors in data grouped according to overweight condition was examined. During a 12.3-year follow-up there were 2,040 deaths. including 947 from cancers and 304 from CVD. MetS significantly increased the hazard ratios for all-cause mortality in women and CVD mortality in men. Non-overweight with >= 2 risk factors had a similar impact on all-cause and CVD mortality. Clustering of metabolic factors caused a linear increase in the hazard ratios for mortality.Conclusions: MetS caused moderate increases in all-cause and CVD mortality. However, the MetS definition requiring obesity may not necessarily identify non-overweight individuals who have a high mortality risk and are more prevalent than subjects with MetS. (Circ J 2009; 73: 878-884)