Hantaviruses and cardiopulmonary syndrome in South America
Hantaviruses and cardiopulmonary syndrome in South America
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DOI：
10.1016/j.virusres.2014.01.015
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发表时间：
2014-07-17
期刊：
影响因子：
5
通讯作者：
Alcira Enria, Delia
中科院分区：
文献类型：
--
作者：
Moraes Figueiredo, Luiz Tadeu;de Souza, William Marciel;Alcira Enria, Delia
汉坦病毒（布尼亚病毒科）心肺综合征（HCPS）是一个新兴的健康问题，在南美洲由于城市的增长和扩大的农业和养牛区的生态系统包含大多数物种的Sigmodontinae啮齿动物作为汉坦病毒水库。截至2013年，南美洲已报告约4000例HCPS病例，与以下汉坦病毒有关：安第斯山脉、阿纳哈图巴、阿拉拉夸拉（ARQV）、帕拉纳亚、贝尔梅霍、卡斯泰洛多斯索尼奥斯、朱基蒂巴、阿劳卡里亚、拉古纳内格拉、Lechiguanas、马里帕、奥兰、里奥马莫尔和图纳里。汉坦病毒通过接触或通过受感染啮齿动物的排泄物和分泌物的气溶胶传播给人类。阿根廷和智利也报告了汉坦病毒的人际传播。HCPS的病程伴随着由汉坦病毒感染肺内皮细胞引起的毛细血管渗漏综合征，并且大多伴随着与细胞因子风暴相关的严重炎症过程。HCPS开始为登革热样急性发热性疾病，但约3天后进展为呼吸衰竭和心源性休克，导致感染ARQV的患者的高死亡率达到50%。(C)2014爱思唯尔有限公司版权所有。
Hantavirus (Bunyaviridae) cardiopulmonary syndrome (HCPS) is an emerging health problem in South America due to urban growth and to the expansion of agriculture and cattle-raising areas into ecosystems containing most of the species of Sigmodontinae rodents that act as hantavirus reservoirs. About 4000 HCPS cases have been reported in South America up to 2013, associated with the following hantaviruses: Andes, Anajatuba, Araraquara (ARQV), Paranoa, Bermejo, Castelo dos Sonhos, Juquitiba, Araucaria, Laguna Negra, Lechiguanas, Maripa, Oran, Rio Mamore and Tunari. The transmission of hantavirus to man occurs by contact with or through aerosols of excreta and secretions of infected rodents. Person-to-person transmission of hantavirus has also been reported in Argentina and Chile. HCPS courses with a capillary leaking syndrome produced by the hantavirus infecting lung endothelial cells and mostly with a severe inflammatory process associated with a cytokine storm. HCPS starts as a dengue-like acute febrile illness but after about 3 days progresses to respiratory failure and cardiogenic shock, leading to a high fatality rate that reaches 50% for patients infected with ARQV. (C) 2014 Elsevier B.V. All rights reserved.