Chronicity of depressive problems and the cortisol response to psychosocial stress in adolescents: The TRAILS study
Chronicity of depressive problems and the cortisol response to psychosocial stress in adolescents: The TRAILS study
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DOI：
10.1016/j.psyneuen.2012.08.004
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发表时间：
2013-05-01
影响因子：
3.7
通讯作者：
Oldehinkel, Albertine J.
中科院分区：
文献类型：
--
作者：
Booij, Sanne H.;Bouma, Esther M. C.;Oldehinkel, Albertine J.
荟萃分析研究进一步支持的临床和流行病学研究表明，抑郁症的慢性（即持续性或复发）与下丘脑垂体肾上腺（HPA）轴对心理社会压力的反应之间可能存在关联。在本研究中，我们研究了抑郁问题的长期性是否以及如何预测青少年皮质醇对标准化社会压力测试的反应。数据是在跟踪青少年个人生活调查 (TRAILS) 队列的高风险焦点样本 (n = 351) 中收集的，这是一项每两年到三年进行一次大型前瞻性人口研究。抑郁问题在 11、13.5 和 16 岁左右进行评估。在格罗宁根社会压力测试 (GSST) 之前、期间和之后采样，测量唾液中的皮质醇水平，以确定皮质醇对心理社会压力的反应。相对于皮质醇反应的增加 (AUCi)（即相对于基线的变化）的曲线下面积被用作 HPA 轴反应的量度。通过线性回归分析和重复测量方差分析，研究了抑郁问题的长期性是否可以预测 16 岁左右皮质醇对 GSST 的反应。抑郁问题的长期性与皮质醇应激反应显着相关。这种关系是曲线形的，新近出现的抑郁问题预示着皮质醇反应的增加，而慢性抑郁问题则预示着皮质醇反应的减弱。这项研究的结果表明，抑郁问题最初会增加皮质醇对压力的反应，但当抑郁问题长期持续存在时，这种模式就会逆转。 (C) 2012 Elsevier Ltd. 保留所有权利。
Clinical and epidemiological studies, further supported by meta-analytic studies, indicate a possible association between chronicity (i.e., persistence or recurrence) of depression and hypothalamic pituitary adrenal (HPA) axis responsiveness to psychosocial stress. In the present study, we examined whether and how chronicity of depressive problems predicts cortisol responses to a standardized social stress test in adolescents. Data were collected in a high-risk focus sample (n = 351) of the Tracking Adolescents' Individual Lives Survey (TRAILS) cohort, a large prospective population study with bi- to triennial measurements. Depressive problems were assessed around age 11, 13.5, and 16. Cortisol levels were measured in saliva, sampled before, during, and after the Groningen Social Stress Test (GSST), to determine the cortisol response to psychosocial stress. The area under the curve with respect to the increase (AUCi) (i.e., change from baseline) of the cortisol response was used as a measure of HPA axis response. By means of linear regression analysis and repeated-measures analysis of variance, it was examined whether chronicity of depressive problems predicted the cortisol response to the GSST around the age of 16. Chronicity of depressive problems was significantly associated with cortisol stress responses. The relationship was curvilinear, with recent-onset depressive problems predicting an increased cortisol response, and more chronic depressive problems a blunted response. The results of this study suggest that depressive problems initially increase cortisol responses to stress, but that this pattern reverses when depressive problems persist over prolonged periods of time. (C) 2012 Elsevier Ltd. All rights reserved.