THE UTILITY OF COLLAGEN-BASED VEHICLES IN DELIVERY OF GROWTH FACTORS FOR HARD AND SOFT TISSUE WOUND REPAIR
THE UTILITY OF COLLAGEN-BASED VEHICLES IN DELIVERY OF GROWTH FACTORS FOR HARD AND SOFT TISSUE WOUND REPAIR
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DOI：
10.1016/0267-6605(92)90103-z
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发表时间：
1992-01-01
期刊：
影响因子：
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通讯作者：
MCPHERSON J M
中科院分区：
文献类型：
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作者：
MCPHERSON J M
在过去的几年中，牛脱矿骨粉和重组牛真皮胶原蛋白已被有效地用于在硬组织和软组织伤口修复的动物模型中提供各种生长因子。在大鼠皮下模型中，骨形态发生蛋白被递送到脱矿骨粉基质中以促进异位骨形成，目的是研究软骨内骨形成的过程并评估这些因子在促进硬组织缺损修复中的效用。重构的牛真皮胶原蛋白凝胶和海绵，包括胶原蛋白和肝素的复合物，已被用于递送生长因子，如血小板衍生生长因子（PDGF）、转化生长因子-β（TGF-β）、血小板衍生生长因子（PDGF）和血小板衍生生长因子（TGF-β）。和成纤维细胞生长因子（FGF），以研究其在皮肤伤口修复的皮下和切口模型中的作用。这些实验动物研究的结果提供了令人信服的证据，即I型胶原蛋白的流变学性质、生物相容性和可吸收性使其成为在硬组织和软组织伤口修复的人类临床研究中评价各种生长因子的优良递送载体。
Bovine demineralized bone powder and reconstituted bovine dermal collagen have been effectively utilized during the past several years to deliver a variety of growth factors in animal models of hard and soft tissue wound repair. Bone morphogenetic proteins have been delivered in a demineralized bone powder matrix to promote ectopic bone formation in the rat subcutaneous model with the objective of studying the process of endochondral bone formation and evaluating the utility of such factors in promoting repair of hard tissue defects. Reconstituted bovine dermal collagen gels and sponges, including composites of collagen and heparin, have been utilized to deliver growth factors such as platelet-derived growth factor (PDGF), transforming growth factor-beta (TGF-.beta.) and fibroblast growth factor (FGF) to study their effects in subcutaneous and incisional models of dermal wound repair. The results of these experimental animal studies have provided convincing evidence that the rheological properties, biocompatibility and resorbable nature of type I collagen make it an excellent delivery vehicle for evaluation of a variety of growth factors in human clinical studies of hard and soft tissue wound repair.