Associations of Expressions of HBcAg and HBsAg with the Histologic Activity of Liver Disease and Viral Replication
Associations of Expressions of HBcAg and HBsAg with the Histologic Activity of Liver Disease and Viral Replication
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DOI：
10.5009/gnl.2008.2.3.166
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发表时间：
2008-12-01
期刊：
影响因子：
3.4
通讯作者：
Rim, Kyu Sung
中科院分区：
文献类型：
--
作者：
Son, Su Myung;Yoo, Jeong Hwan;Rim, Kyu Sung
背景/目标：B型肝炎病毒（HBV）核心抗原（HBcAg）和表面抗原（HBsAg）的亚细胞定位与肝病的活动性和HBV复制水平有关。本研究的目的是确定组织学活动，病毒复制，HBcAg和HBsAg的细胞内分布之间的相关性。方法：我们纳入了1997年至2007年在盆唐CHA医院接受肝活检的670例慢性B型肝炎患者。对病历资料进行回顾性分析。结果：纤维化分期较高（3.31 ± 1.34 vs. 2.43 ± 1.39，平均值± SD，p
Background/Aims: Subcellular localization of hepatitis B virus (HBV) core antigen (HBcAg) and HBV surface antigen (HBsAg) is known to be related to the activity of liver disease and the level of HBV replication. The aim of this study was to determine the correlation between histologic activity, viral replication, and the intracellular distributions of HBcAg and HBsAg. Methods: We enrolled 670 patients with chronic hepatitis B who underwent liver biopsy at Bundang CHA hospital between 1997 to 2007. The data from medical records were reviewed retrospectively. Results: The stage of fibrosis was higher (3.31+/-1.34 vs. 2.43+/-1.39, mean+/-SD, p