Prognostic value of tumor necrosis at CT in diffuse large B-cell lymphoma
Prognostic value of tumor necrosis at CT in diffuse large B-cell lymphoma
复制标题
DOI：
10.1016/j.ejrad.2014.12.009
复制
发表时间：
2015-03-01
影响因子：
3.3
通讯作者：
Kwee, Thomas C.
中科院分区：
文献类型：
--
作者：
Adams, Hugo J. A.;de Klerk, John M. H.;Kwee, Thomas C.
目的：为了确定肿瘤坏死的预后价值，在计算机断层扫描（CT）在新诊断的弥漫性大B细胞淋巴瘤（DLBCL）的材料和方法：本回顾性研究包括51例新诊断的DLBCL谁经历了未经增强和静脉造影剂增强CT前R-CHOP（利妥昔单抗，环磷酰胺，羟基柔红霉素，长春新碱和泼尼松龙）化学免疫治疗。在CT上目视和定量评估肿瘤坏死的存在。评估CT肿瘤坏死状态与国家综合癌症网络（NCCN）国际预后指数（IPI）因素之间的关系。采用考克斯回归分析确定NCCN-IPI评分和CT肿瘤坏死状态对预后的影响。CT检查肿瘤坏死状态与NCCN-IPI的年龄分类因子之间没有相关性（rho =-0.042，P = 0.765），分类乳酸脱氢酶（LDH）比值（rho = 0.201，P = 0.156），主要器官结节病（phi=-0.245，P=0.083），安阿伯III/IV期疾病（phi =-0.208，P =0.141）和东部肿瘤协作组（ECOG）体力状态（phi = 0.015，P= 0.914）。在多变量考克斯比例风险模型中，只有CT肿瘤坏死状态是无进展生存期（P=0.003）和总生存期（P= 0.004）的独立预测因素。(C)2014爱思唯尔爱尔兰有限公司版权所有。
Objective: To determine the prognostic value of tumor necrosis at computed tomography (CT) in newly diagnosed diffuse large B-cell lymphoma (DLBCL).Materials and methods: This retrospective study included 51 patients with newly diagnosed DLBCL who had undergone both unenhanced and intravenous contrast-enhanced CT before R-CHOP (rituximab, cyclophosphamide, hydroxydaunorubicin, oncovin and prednisolone) chemo-immunotherapy. Presence of tumor necrosis was visually and quantitatively assessed at CT. Associations between tumor necrosis status at CT and the National Comprehensive Cancer Network (NCCN) International Prognostic Index (IPI) factors were assessed. Cox regression analysis was used to determine the prognostic impact of NCCN-IPI scores and tumor necrosis status at CT.Results: There were no correlations between tumor necrosis status at CT and the NCCN-IPI factors categorized age (rho = -0.042, P = 0.765), categorized lactate dehydrogenase (LDH) ratio (rho = 0.201, P = 0.156), extranodal disease in major organs (phi= -0.245, P=0.083), Ann Arbor stage III/IV disease (phi = -0.208, P=0.141), and Eastern Cooperative Oncology Group (ECOG) performance status(phi = 0.015, P= 0.914). In the multivariate Cox proportional hazards model, only tumor necrosis status at CT was an independent predictive factor of progression-free survival (P=0.003) and overall survival (P= 0.004).Conclusion: The findings of this study indicate the prognostic potential of tumor necrosis at CT in newly diagnosed DLBCL. (C) 2014 Elsevier Ireland Ltd. All rights reserved.