The LDL receptor-related protein (LRP) family: An old family of proteins with new physiological functions
The LDL receptor-related protein (LRP) family: An old family of proteins with new physiological functions
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DOI：
10.1080/07853890701214881
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发表时间：
2007-01-01
影响因子：
4.4
通讯作者：
Boucher, Philippe
中科院分区：
文献类型：
--
作者：
May, Petra;Woldt, Estelle;Boucher, Philippe
低密度脂蛋白（LDL）受体是七种结构上密切相关的跨膜蛋白家族（LR-P1、LRP 1b、巨蛋白/LRP 2、LDL受体、极低密度脂蛋白受体、MEGF 7/LRP 4、LRP 8/载脂蛋白E受体2）的创始成员。这些蛋白质参与广泛的生理过程，包括调节脂质代谢、防止动脉粥样硬化、神经发育以及营养物质和维生素的运输。虽然目前可用的数据表明LDL受体的作用仅限于通过受体介导的脂蛋白颗粒内吞作用调节胆固醇稳态，但越来越多的实验证据表明该基因家族的其他成员具有作为信号转导子的额外生理功能。在这篇综述中，我们专注于这个家庭的两个主要成员，LRP 1和megalin/LRP 2的最新发现的功能，并在新阐明的生理作用的家庭，MEGF 7/LRP 4，这也可以作为一个调制器的不同信号通路在发展过程中。
The low-density lipoprotein (LDL) receptor is the founding member of a family of seven structurally closely related transmembrane proteins (LR-Pl, LRP1b, megalin/LRP2, LDL receptor, very low-density lipoprotein receptor, MEGF7/ LRP4, LRP8/apolipoprotein E receptor2). These proteins participate in a wide range of physiological processes, including the regulation of lipid metabolism, protection against atherosclerosis, neurodevelopment, and transport of nutrients and vitamins. While currently available data suggest that the role of the LDL receptor is limited to the regulation of cholesterol homeostasis by receptor-mediated endocytosis of lipoprotein particles, there is growing experimental evidence that the other members of the gene family have additional physiological functions as signal transducers. In this review, we focus on the latest discovered functions of two major members of this family, LRP1 and megalin/LRP2, and on the newly elucidated physiological role of a third member of the family, MEGF7/LRP4, which can also function as a modulator of diverse signaling pathways during development.