Risk of All-Cause Mortality in Alcohol-Dependent Individuals: A Systematic Literature Review and Meta-Analysis
Risk of All-Cause Mortality in Alcohol-Dependent Individuals: A Systematic Literature Review and Meta-Analysis
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DOI：
10.1016/j.ebiom.2015.08.040
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发表时间：
2015-10-01
期刊：
影响因子：
11.1
通讯作者：
Rehm, Juergen
中科院分区：
文献类型：
--
作者：
Laramee, Philippe;Leonard, Saoirse;Rehm, Juergen
背景：酒精依赖（AD）带来很高的死亡率负担，减少饮酒可以减轻这种负担。我们进行了系统的文献综述和荟萃分析，调查酒精依赖受试者的全因死亡风险。方法：从数据库概念到 2014 年 6 月 26 日，对 MEDLINE、MEDLINE In-Process、Embase 和 PsycINFO 进行检索。符合条件的研究报告了酒精依赖受试者和感兴趣的比较人群的全因死亡率。两个人独立审查研究。在确定的 4540 条记录中，荟萃分析中纳入了 39 项观察性研究。 结果：我们发现，与一般人群相比，酒精依赖受试者的死亡率显着增加（27 项研究；相对风险 [RR] = 3.45；95% CI [2.96, 4.02]；p < 0.0001）。与有资格诊断酒精滥用的受试者或没有酒精使用障碍（AUD）的受试者相比，死亡率增加也很显着。即使排除戒酒者，继续大量饮酒的酒精依赖受试者的死亡率也显着高于减少酒精摄入量的酒精依赖受试者（p < 0.05）。解释：AD 被发现会显着增加个体全因死亡的风险。虽然酒精依赖者的戒酒比不戒酒的死亡率降低幅度更大，但这项研究表明，酒精依赖者可以通过减少饮酒量来显着降低死亡风险。 (C) 2015 年作者。由 Elsevier B.V. 出版
Background: Alcohol dependence (AD) carries a high mortality burden, which may be mitigated by reduced alcohol consumption. We conducted a systematic literature review and meta-analysis investigating the risk of all-cause mortality in alcohol-dependent subjects.Methods: MEDLINE, MEDLINE In-Process, Embase and PsycINFO were searched from database conception through 26th June 2014. Eligible studies reported all-cause mortality in both alcohol-dependent subjects and a comparator population of interest. Two individuals independently reviewed studies. Of 4540 records identified, 39 observational studies were included in meta-analyses.Findings: We identified a significant increase in mortality for alcohol-dependent subjects compared with the general population (27 studies; relative risk [RR] = 3.45; 95% CI [2.96, 4.02]; p < 0.0001). The mortality increase was also significant compared to subjects qualifying for a diagnosis of alcohol abuse or subjects without alcohol use disorders (AUDs). Alcohol-dependent subjects continuing to drink heavily had significantly greater mortality than alcohol-dependent subjects who reduced alcohol intake, even if abstainers were excluded (p < 0.05).Interpretation: AD was found to significantly increase an individual's risk of all-cause mortality. While abstinence in alcohol-dependent subjects led to greater mortality reduction than non-abstinence, this study suggests that alcohol-dependent subjects can significantly reduce their mortality risk by reducing alcohol consumption. (C) 2015 The Authors. Published by Elsevier B.V.