Prophylactic treatment of asthma by an ozone scavenger in a mouse model
Prophylactic treatment of asthma by an ozone scavenger in a mouse model
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DOI：
10.1016/j.bmcl.2014.11.035
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发表时间：
2015-01-15
影响因子：
2.7
通讯作者：
Keinan, Ehud
中科院分区：
文献类型：
--
作者：
Bibi, Haim;Reany, Ofer;Keinan, Ehud
我们的假设是，哮喘中的炎症涉及白细胞产生臭氧，臭氧可能是一种炎症介质，这表明活性氧（ROS）的清除剂，例如富电子烯烃，可以用于哮喘的预防性治疗。烯烃可以对外源或内源臭氧和其他活性氧提供化学保护。BALB/c小鼠在卵清蛋白攻击前吸入d -柠檬烯，可显著减轻过敏性哮喘症状。炎症过程的减轻是明显的醛水平降低，BAL液中中性粒细胞计数减少和组织学检查。脾脏中醛的水平降低，观察到令人惊讶的全身效应，表明检查远离炎症灶的组织和器官可以提供有关氧化应激分布的有价值的信息，并可能作为靶向治疗的指导。(C) 2014 Elsevier Ltd.版权所有。
Our hypothesis that inflammation in asthma involves production of ozone by white blood cells and that ozone could be an inflammatory mediator suggests that scavengers of reactive oxygen species (ROS), for example, electron-rich olefins, could serve for prophylactic treatment of asthma. Olefins could provide chemical protection against either exogenous or endogenous ozone and other ROS. BALB/c mice pre-treated by inhalation of D-limonene before an ovalbumin challenge exhibited significant attenuation of the allergic asthma symptoms. Diminution of the inflammatory process was evident by reduced levels of aldehydes, reduced counts of neutrophils in the BAL fluid and by histological tests. A surprising systemic effect was observed by decreased levels of aldehydes in the spleen, suggesting that the examination of tissues and organs that are remote from the inflammation foci could provide valuable information on the distribution of the oxidative stress and may serve as guide for targeted treatment. (C) 2014 Elsevier Ltd. All rights reserved.