ARCHITECTURE OF CONNECTIVITY WITHIN A CINGULO-FRONTO-PARIETAL NEUROCOGNITIVE NETWORK FOR DIRECTED ATTENTION
ARCHITECTURE OF CONNECTIVITY WITHIN A CINGULO-FRONTO-PARIETAL NEUROCOGNITIVE NETWORK FOR DIRECTED ATTENTION
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DOI：
10.1001/archneur.1993.00540030045013
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发表时间：
1993-03-01
影响因子：
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通讯作者：
MESULAM, MM
中科院分区：
文献类型：
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作者：
MORECRAFT, RJ;GEULA, C;MESULAM, MM
定向注意的空间分布由一个大规模的神经网络来协调。这个网络的三个主要皮质成分位于额叶眼区、后顶叶皮质和扣带皮质。我们将一种逆行转运的荧光染料注入猴子的额叶视野，另一种注入猴子大脑的后顶叶皮层。扣带皮层中的大量神经元被这两种荧光染料逆行标记。这两种类型的逆行标记的神经元广泛混合，但与两种示踪剂标记的神经元构成不到1%的逆行标记扣带神经元。包含逆行神经元标记的其他皮质区域包括运动前区、外侧前额叶、眶额、鳃盖、后顶叶、外侧颞叶、下颞叶、海马旁和岛叶区域。这些区域含有分别用两种染料标记的神经元，但实际上没有同时用两种染料标记的神经元。在丘脑，逆行标记的核未能显示双重标记的证据。两个逆行标记神经元群体之间的重叠在皮质水平比在丘脑水平要广泛得多。这些观察结果表明，皮质和丘脑的预测额眼领域和后顶叶皮质不代表轴突侧支的单个神经元，但起源于两个不同的和部分重叠的神经元群体。
The spatial distribution of directed attention is coordinated by a large-scale neural network. The three principal cortical components of this network are located in the region of the frontal eye fields, posterior parietal cortex, and the cingulate cortex. We injected a retrogradely transported fluorescent dye into the frontal eye fields and another into the posterior parietal cortex of the monkey brain. Large numbers of neurons in the cingulate cortex were retrogradely labeled with each of the two fluorescent dyes. The two types of retrogradely labeled neurons were extensively intermingled, but neurons labeled with both tracers constituted less than 1 % of retrogradely labeled cingulate neurons. Other cortical areas that contained retrograde neuronal labeling included the premotor, lateral prefrontal, orbitofrontal, opercular, posterior parietal, lateral temporal, inferior temporal, parahippocampal, and insular regions. These areas contained neurons labeled with each of the two dyes but virtually no neurons labeled with both. In the thalamus, retrogradely labeled nuclei failed to display evidence of double labeling. The overlap between the two populations of retrogradely labeled neurons was far more extensive at the cortical than at the thalamic level. These observations show that cortical and thalamic projections to the frontal eye fields and posterior parietal cortex do not represent axonal collaterals of single neurons but originate from two distinct and partially overlapping populations of neurons.