Polymer Mechanics as a Model for Short-Term and Flow-Independent Cartilage Viscoelasticity.
Polymer Mechanics as a Model for Short-Term and Flow-Independent Cartilage Viscoelasticity.
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DOI：
10.1016/j.msec.2010.11.029
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发表时间：
2011-05-10
影响因子：
7.9
通讯作者：
Fyhrie, D. P.
中科院分区：
文献类型：
--
作者：
June, R. K.;Neu, C. P.;Barone, J. R.;Fyhrie, D. P.
关节软骨是承载软组织，其覆盖关节中长骨的接触表面。健康的软骨允许平滑的关节运动，而受损的软骨在使人衰弱的关节疾病如骨关节炎中阻止正常功能。通过骨关节炎的进展，并在响应创新的再生治疗软骨机械功能的知识，需要相互作用的细胞外基质成分和间质液的分子性质的全面理解。因此，本研究的目的是（1）使用不同的机械模型检查软骨应力松弛的时间尺度和（2）开发和应用一种新的（称为“粘性”）聚合物力学模型，软骨应力松弛的基础上暂时结合的组成大分子。使用来自小牛软骨样品的数据，我们发现不同的模型捕获软骨应力松弛的不同时间尺度：单分散聚合物蠕动最好地描述了松弛的第一秒，粘性聚合物力学最好地描述了从100秒到100秒的松弛数据，以及通过多孔弹性基质的无粘流体流动的模型最好地描述了从100秒到平衡的数据。使用实验数据观察到粘性聚合物模型的进一步支持，其中在低或高盐浓度下测量软骨应力松弛。这些数据表明，一个完整的理解软骨力学，特别是在短时间尺度后立即加载，需要升值的流体流动和细胞外基质的聚合行为。
Articular cartilage is the load bearing soft tissue that covers the contacting surfaces of long bones in articulating joints. Healthy cartilage allows for smooth joint motion, while damaged cartilage prohibits normal function in debilitating joint diseases such as osteoarthritis. Knowledge of cartilage mechanical function through the progression of osteoarthritis, and in response to innovative regeneration treatments, requires a comprehensive understanding of the molecular nature of interacting extracellular matrix constituents and interstitial fluid. The objectives of this study were therefore to (1) examine the timescale of cartilage stress-relaxation using different mechanistic models and (2) develop and apply a novel (termed “sticky”) polymer mechanics model to cartilage stress-relaxation based on temporary binding of constituent macromolecules. Using data from calf cartilage samples, we found that different models captured distinct timescales of cartilage stress-relaxation: monodisperse polymer reptation best described the first second of relaxation, sticky polymer mechanics best described data from ∼1-100 seconds of relaxation, and a model of inviscid fluid flow through a porous elastic matrix best described data from 100 seconds to equilibrium. Further support for the sticky polymer model was observed using experimental data where cartilage stress-relaxation was measured in either low or high salt concentration. These data suggest that a complete understanding of cartilage mechanics, especially in the short time scales immediately following loading, requires appreciation of both fluid flow and the polymeric behavior of the extracellular matrix.
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影响因子：
7
作者：
June, R. K.;Mejia, K. L.;Fyhrie, D. P.
通讯作者：
Fyhrie, D. P.
影响因子：
2.2
作者：
Li, LP;Herzog, W;Jurvelin, JS
通讯作者：
Jurvelin, JS
影响因子：
6.8
作者：
AKAIKE, H
通讯作者：
AKAIKE, H
DOI：
10.1186/ar380
发表时间：
2002
期刊：
Arthritis research
影响因子：
--
作者：
Eyre D
通讯作者：
Eyre D
影响因子：
5.5
作者：
de Gennes, PG
通讯作者：
de Gennes, PG