Tubular site(s) of action of atrial natriuretic peptide in the rat.
Tubular site(s) of action of atrial natriuretic peptide in the rat.
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大鼠心房钠尿肽的管状作用位点。
DOI：
10.1152/ajprenal.1988.255.2.f313
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Stein,JH
中科院分区：
文献类型：
--
作者：
Fried,TA;Osgood,RW;Stein,JH
通过微穿刺技术，本研究检测了用Wy 47663（一种心房利钠肽（ANP）的合成类似物）或单独给药的大鼠，氯离子向浅表晚期远端小管和乳头集管的基部和尖端的传递。两组患者全肾小球滤过率（GFR）和单肾小球滤过率差异无统计学意义。ANP-(5.71 +/- 1.15%)和载药-(6.28 +/- 1.12%)处理动物的晚期远端氯离子输送量也没有差异。然而，anp处理的大鼠（14.37 +/- 1.98%）与载药处理的大鼠（7.32 +/- 1.47%）相比，乳头集管底部的部分递送量显著增加（14.37 +/- 1.98%）。anp处理大鼠的尖端乳头收集管输送量也显著增加（1.97 +/- 1.96比3.09 +/- 0.60%）。此外，经anp处理的大鼠沿乳头收集管重吸收的氯离子的百分比明显减少。综上所述，ANP抑制了表面晚期远端小管与乳头集管基部之间的一些小管段以及乳头集管可达部分的重吸收。
With micropuncture techniques, the present study examined the delivery of chloride to the superficial late distal tubule and the base and tip of the papillary collecting duct in rats treated with either Wy 47663, a synthetic analogue of atrial natriuretic peptide (ANP), or vehicle alone. Whole kidney glomerular filtration rate (GFR) and single-nephron glomerular filtration rate were not significantly different between the two groups. Late distal tubule chloride delivery was also not different between ANP- (5.71 +/- 1.15%) and vehicle- (6.28 +/- 1.12%) treated animals. However, fractional delivery to the base of the papillary collecting duct was significantly greater in the ANP-treated rats (14.37 +/- 1.98%) compared with vehicle-treated rats (7.32 +/- 1.47%). Tip papillary collecting duct delivery was also significantly greater in the ANP-treated rats (1.97 +/- 1.96 vs. 3.09 +/- 0.60%). In addition, the percent of chloride delivered that was reabsorbed along the papillary collecting duct was significantly less in the ANP-treated rats. In conclusion, ANP inhibits reabsorption in some tubular segments between the superficial late distal tubule and papillary collecting duct base as well as in the accessible portion of the papillary collecting duct.