Genetic variants associated with patent ductus arteriosus in extremely preterm infants
Genetic variants associated with patent ductus arteriosus in extremely preterm infants
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DOI：
10.1038/s41372-018-0285-6
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发表时间：
2019-03-01
影响因子：
2.9
通讯作者：
Poulsen, JoAnn
中科院分区：
文献类型：
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作者：
Dagle, John M.;Ryckman, Kelli K.;Poulsen, JoAnn
目的：动脉导管未闭（PDA）是早产儿常见的疾病。先前的研究表明遗传学在决定自发性导管关闭中的作用。使用样本从一个大的新生儿队列，我们测试的假设，即常见的遗传变异与PDA在极早产infants. Study design：早产儿（n = 1013）在NICHD新生儿研究网络网站注册的PDA表型。对候选基因的1634个单核苷酸多态性（SNPs）进行基因分型。结果：几个基因的SNPs与PDA的临床诊断和极早产儿PDA的手术结扎相关（p <0.01）。校正后的多重comparation.Conclusion：我们确定了几个常见的遗传变异与PDA的协会是显着的。这些发现可能为进一步研究早产儿PDA的遗传风险因素提供信息。
Objective: Patent ductus arteriosus (PDA) is a commonly observed condition in preterm infants. Prior studies have suggested a role for genetics in determining spontaneous ductal closure. Using samples from a large neonatal cohort we tested the hypothesis that common genetic variations are associated with PDA in extremely preterm infants.Study design: Preterm infants (n = 1013) enrolled at NICHD Neonatal Research Network sites were phenotyped for PDA. DNA was genotyped for 1634 single nucleotide polymorphisms (SNPs) from candidate genes. Analyses were adjusted for ancestral eigenvalues and significant epidemiologic variables.Results: SNPs in several genes were associated with the clinical diagnosis of PDA and with surgical ligation in extremely preterm neonates diagnosed with PDA (p < 0.01). None of the associations were significant after correction for multiple comparisons.Conclusion: We identified several common genetic variants associated with PDA. These findings may inform further studies on genetic risk factors for PDA in preterm infants.