Evolution of cooperation on an epithelium.
Evolution of cooperation on an epithelium.
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发表时间：
2018-12
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通讯作者：
J. Renton;K. Page
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作者：
J. Renton;K. Page
合作在自然界中是普遍存在的，不仅在动物王国的社会互动中，而且在细胞水平上。例如，在癌症中，肿瘤细胞可以通过产生生长因子来合作。传统上，合作的演化研究了良好的混合种群的进化博弈论的框架下，最近的结构化种群使用进化图论。然而，由于组织中的细胞排列而产生的群体结构是动态的，因此不能由这些框架中的任一个准确地表示。在这项工作中，我们比较合作成功的条件，在上皮细胞建模使用进化图论，那些在一个机械模型的上皮细胞=-Voronoi镶嵌模型。至关重要的是，在后一种模型中，细胞能够移动，出生和死亡在空间上并不耦合。我们计算固定概率的Voronoi镶嵌模型通过模拟和近似分析技术，并表明，这导致更强的促进合作的进化图论模型相比。
Cooperation is prevalent in nature, not only in the context of social interactions within the animal kingdom, but also on the cellular level. In cancer for example, tumour cells can cooperate by producing growth factors. The evolution of cooperation has traditionally been studied for well-mixed populations under the framework of evolutionary game theory, and more recently for structured populations using evolutionary graph theory. The population structures arising due to cellular arrangement in tissues however are dynamic and thus cannot be accurately represented by either of these frameworks. In this work we compare the conditions for cooperative success in an epithelium modelled using evolutionary graph theory, to those in a mechanical model of an epithelium =- the Voronoi tessellation model. Crucially, in this latter model cells are able to move, and birth and death are not spatially coupled. We calculate fixation probabilities in the Voronoi tessellation model through simulation and an approximate analytic technique and show that this leads to stronger promotion of cooperation in comparison with the evolutionary graph theory model.