DEVELOPMENTAL EFFECTS OF CONGENITAL HYDROCEPHALUS (CH) IN MOUSE
DEVELOPMENTAL EFFECTS OF CONGENITAL HYDROCEPHALUS (CH) IN MOUSE
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DOI：
10.1016/0012-1606(70)90142-9
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发表时间：
1970-01-01
影响因子：
2.7
通讯作者：
GREEN, MC
中科院分区：
文献类型：
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作者：
GREEN, MC
隐性突变基因先天性脑积水（ch）会导致严重的胚胎性脑积水和广泛的骨骼缺陷。在这项研究中，它也被证明会导致泌尿生殖系统缺陷。泌尿生殖系统缺陷可追溯到 10 天胚胎中形成的过量中肾小管，其填充了正常中肾和肾脏之间的整个区域。在同一阶段的内侧邻近区域，腹腔神经节的前体细胞缺乏。讨论了神经节细胞缺乏可能导致多余小管形成的可能性。脑积水开始于第 11 天阶段，大约此时脑脊液通常开始通过后脑顶部的前孔流入预期的蛛网膜下腔。在ch ch 胚胎中，大脑半球和随后的大脑其他部分变得异常扩张，并且蛛网膜下腔不发育。脑脊液显然无法流入蛛网膜下腔，但其原因尚不清楚。杂合子（ch+）中的突变基因导致泌尿生殖系统和骨骼异常的频率较低，与纯合子相似，但不太严重。尚未发现单一基因作用的令人满意的假设。
The recessive mutant gene congenital hydrocephalus (ch) causes severe embryonic hydrocephalus and widespread skeletal defects. In this study it is shown also to cause defects of the urogenital system. The urogenital defects trace to the formation in 10-day embryos of excess mesonephric tubules filling the whole region between the normal mesonephros and the kidney. In the medial adjacent region at the same stage, there is a deficiency of precursor cells of the celiac ganglion. The possibility that the deficiency of ganglion cells may cause the formation of excess tubules is discussed. Hydrocephalus begins at the 11-day stage at about the time the cerebrospinal fluid normally begins to flow through the foramen anterius in the roof of the hindbrain into the prospective subarachnoid space. In ch ch embryos, the cerebral hemispheres and later other parts of the brain become abnormally dilated and the subarachnoid space does not develop. Cerebrospinal fluid apparently fails to flow into the subarachnoid space, but the reason for this is not obvious. The mutant gene in heterozygotes (ch+) causes a low frequency of abnormalities of the urogenital system and skeleton similar to those of homozygotes but less severe. No satisfactory hypothesis of unitary gene action has been found.