Inter-individual variability in optimal current direction for transcranial magnetic stimulation of the motor cortex
Inter-individual variability in optimal current direction for transcranial magnetic stimulation of the motor cortex
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DOI：
10.1016/j.jneumeth.2007.01.021
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发表时间：
2007-05-15
影响因子：
3
通讯作者：
Miall, R. Chris
中科院分区：
文献类型：
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作者：
Balslev, Daniela;Braet, Wouter;Miall, R. Chris
我们评估了运动皮质双相经颅磁刺激(TMS)最佳电流方向的个体间变异性。在8个线圈方向上以45度为增量目测第一背侧骨间肌的运动阈值。每个参与者(n=13)完成了两次实验。一名重测相关性低的参与者被排除在外(皮尔逊的r<；0.5)。在四名受试者中，视觉检测运动阈值与肌电检测进行比较；运动阈值非常相似且高度相关(0.94-0.99)。与之前的研究类似，当第一个电流脉冲向大脑后外侧流动时，大多数参与者的刺激最有效。然而，在四名参与者中，最佳线圈方向偏离了这一模式。所有八个方向的主成分分析表明，在我们的样本中，电流方向的最佳方向是围绕后外侧方向的正态分布，范围为63度(S.D.=13.70度)。每当目标部位的刺激强度以运动阈值的百分比计算时，为了将强度和副作用降至最低，可能值得检查线圈从传统的后外侧方向旋转45度是否会降低运动阈值。(C)2007 Elsevier B.V.保留所有权利。
We evaluated inter-individual variability in optimal current direction for biphasic transcranial magnetic stimulation (TMS) of the motor cortex. Motor threshold for first dorsal interosseus was detected visually at eight coil orientations in 45 degrees increments. Each participant (n = 13) completed two experimental sessions. One participant with low test-retest correlation (Pearson's r < 0.5) was excluded. In four subjects, visual detection of motor threshold was compared to EMG detection; motor thresholds were very similar and highly correlated (0.94-0.99). Similar with previous studies, stimulation in the majority of participants was most effective when the first current pulse flowed towards posterolateral in the brain. However, in four participants, the optimal coil orientation deviated from this pattern. A principal component analysis using all eight orientations suggests that in our sample the optimal orientation of current direction was normally distributed around the postero-lateral orientation with a range of 63 degrees (S.D. = 13.70 degrees). Whenever the intensity of stimulation at the target site is calculated as a percentage from the motor threshold, in order to minimize intensity and side-effects it may be worthwhile to check whether rotating the coil 45 degrees from the traditional posterior-lateral orientation decreases motor threshold. (C) 2007 Elsevier B.V. All rights reserved.