Antitumor activity and pharmacokinetics of 7-N-(p-hydroxyphenyl)mitomycin C in human tumor xenografts transplanted into nude mice.
Antitumor activity and pharmacokinetics of 7-N-(p-hydroxyphenyl)mitomycin C in human tumor xenografts transplanted into nude mice.
复制标题
7-N-(对羟基苯基)丝裂霉素 C 在裸鼠移植瘤中的抗肿瘤活性和药代动力学。
DOI：
10.7164/antibiotics.38.401
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
F. Asanuma
中科院分区：
文献类型：
--
作者：
F. Asanuma
The effects of 7-N-(p-hydroxyphenyl)mitomycin C (M-83), a derivative of mitomycin C, against eight human tumor xenografts serially transplanted into male BALB/c nude mice were evaluated. M-83 showed positive antitumor effect against six out of eight tumor strains. The antitumor spectrum of this agent was similar to that of mitomycin C except for two strains. The serum level of M-83 detected by bioassay was biphasic, elimination half-life T1/2 beta was 10.9 minutes and the area under curve AUC60(0) was 112.4 micrograms . minute/ml when 15 mg/kg of the agent was administered. In the tumor, the peak concentration and AUC60(0) detected by radioassay correlated well with the value of drug efficacy TRW/CRW. The ratio of the concentrations detected by bioassay to radioassay in the tumor was approximately 10%, which was thought to be affected by inactivation of the agent in the tumor.
