Ferrying wingless across the synaptic cleft.
Ferrying wingless across the synaptic cleft.
复制标题
无翼地渡过突触间隙。
DOI：
10.1016/j.cell.2009.09.032
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发表时间：
2009
期刊：
影响因子：
64.5
通讯作者：
Zinsmaier,KonradE
中科院分区：
文献类型：
--
作者：
Zarnescu,DanielaC;Zinsmaier,KonradE
分泌的Wnt形态因子介导细胞间通讯，但Wnt在细胞间传递的机制尚不清楚。Korkut等人（2009）报道，跨膜蛋白Evi是一种多功能载体，可引导Wingless到达运动神经元的突触前末端，然后护送其穿过突触间隙。在突触后肌肉中，Evi促进frizzed -2的运输。
Secreted Wnt morphogens mediate cell-cell communication, but the mechanism of Wnt transfer between cells is unknown. Korkut et al. (2009) report that the transmembrane protein Evi is a versatile carrier that guides Wingless to presynaptic terminals of motor neurons and then escorts it across the synaptic cleft. In postsynaptic muscles, Evi promotes Frizzled-2 trafficking.