Smaller sized inhaled anesthetics have more potency on senescence-accelerated prone-8 mice compared with senescence-resistant-1 mice.
Smaller sized inhaled anesthetics have more potency on senescence-accelerated prone-8 mice compared with senescence-resistant-1 mice.
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DOI：
10.3233/jad-130902
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发表时间：
2014
期刊：
影响因子：
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通讯作者：
Huan Xu;Bingwei Lu;Beijie Zheng;Jie Tian;B. Qi;Yuxiao Deng;Zhenzhou He;D. Su;Xiangrui Wang-Xiangrui
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文献类型：
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作者：
Huan Xu;Bingwei Lu;Beijie Zheng;Jie Tian;B. Qi;Yuxiao Deng;Zhenzhou He;D. Su;Xiangrui Wang-Xiangrui
越来越多的老年阿尔茨海默病（AD）患者由于各种原因必须接受全身麻醉手术。了解常用吸入麻醉药对AD患者的药效，对减少吸入麻醉药的用量具有重要意义。先前的研究表明，转基因AD小鼠比野生型小鼠对常见的吸入麻醉剂更具抵抗力。然而，转基因AD小鼠与早发性家族性AD相关，仅占临床AD患者总数的5%。用其他AD动物模型证实结果仍是必要的。目的评价常用吸入麻醉药对另一种AD动物模型--加速衰老小鼠Prone-8（SAMP-8）模型的作用。方法采用夹尾法测定4、6、8、10月龄SAMP-8和SAMR-1小鼠的最低肺泡浓度（MAC）。使用双因素方差分析（年龄和品系作为两个因素）来分析差异。结果统计学结果表明，年龄和应变因素对MAC值均有显著影响。对于三种吸入麻醉剂，SAMP-8小鼠的MAC显著低于SAMR-1小鼠。SAMP-8小鼠的MAC值随着年龄的增长而显著降低。结论SAMP-8小鼠对三种吸入麻醉药的敏感性高于SAMR-1小鼠。
BACKGROUND Increasingly more aged people with Alzheimer's disease (AD) must undergo surgery with general anesthesia for various reasons. Knowing the potency of common inhaled anesthetics on AD patients is important to minimize the quantity of inhaled anesthetics. Previous studies indicated that transgenic AD mice were more resistant to the common inhaled anesthetics than were wild-type mice. However, transgenic AD mice are associated with early-onset familial AD, which accounts for only 5% of the total AD patients in the clinic. Confirming the results using other animal AD models is still necessary. OBJECTIVE The aim of this study was to evaluate the potency of common inhaled anesthetics in another AD animal model, the senescence-accelerated mouse prone-8 (SAMP-8) model. METHODS The minimum alveolar concentration (MAC) was measured by tail clamping in the SAMP-8 and senescence-resistant-1 (SAMR-1) mice at 4, 6, 8, and 10 months of age (n = 13). A two-way ANOVA (age and strain as the two factors) was used to analyze the difference. RESULTS The statistical results showed that both the age and strain factors had significant effects on the MAC values. The MAC of the SAMP-8 mice was significantly lower than that of the SAMR-1 mice for the three inhaled anesthetics. The MAC values of the SAMP-8 mice decreased significantly with aging. CONCLUSIONS The SAMP-8 mice were more sensitive to the three inhaled anesthetics than were the SAMR-1 mice.