Micranthanone A, a New Diterpene with an Unprecedented Carbon Skeleton from Rhododendron micranthum
Micranthanone A, a New Diterpene with an Unprecedented Carbon Skeleton from Rhododendron micranthum
复制标题
米兰他酮 A，一种来自米兰杜鹃的新型二萜，具有前所未有的碳骨架
DOI：
10.1021/ol401292y
复制
发表时间：
2013-06-21
期刊：
影响因子：
5.2
通讯作者：
Zhang, Yonghui
中科院分区：
文献类型：
--
作者：
Zhang, Mengke;Zhu, Yan;Zhang, Yonghui
本文报道了一个新的具有前所未有的碳骨架的二萜化合物micranthanone A（1），两个新的具有不寻常的5，6（3，4-二羟基亚苄基缩醛）基序的grayanane型二萜化合物rhoorranols A（2）和El（3），以及三个已知的grayanane型二萜化合物（4-6）。通过光谱分析、ECD计算和单晶X-射线衍射确定了它们的结构。评价了化合物1-6的体外免疫调节活性，并提出了化合物1的合理的生物遗传学途径。
A new diterpene with an unprecedented carbon skeleton, micranthanone A (1), two new grayanane diterpenoids bearing an unusual 5,6(3,4-dihydroxylbenzylidene acetal) motif, rhodomicranols A (2) and El (3), and three known grayanane diterpenoids (4-6) were Isolated from Rhododendron micranthum. Their structures were elucidated by spectroscopic analyses, calculated ECD, and single-crystal X-ray diffraction. The in vitro immunomodulatory activities of 1-6 were evaluated, and a plausible biogenetic pathway for 1 Is proposed.