Thermal Sensitivity of Heat Sensor TRPA1 Correlates With Temperatures Inducing Heat Avoidance Behavior in Terrestrial Ectotherms
Thermal Sensitivity of Heat Sensor TRPA1 Correlates With Temperatures Inducing Heat Avoidance Behavior in Terrestrial Ectotherms
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DOI：
10.3389/fevo.2021.583837
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发表时间：
2021-06-10
影响因子：
3
通讯作者：
Akashi, Hiroshi
中科院分区：
文献类型：
--
作者：
Akashi, Hiroshi
温度是控制生物体性能的重要环境因素。由于变温动物很大程度上依赖于外部热源来调节其体温，因此热感知是行为体温调节的主要过程。瞬时受体电位锚蛋白1（TRPA 1）是大多数非哺乳动物体内的一种热敏感离子通道，其热激活被认为可诱导变温动物的热回避行为。然而，TRPA 1和生态相关的温度之间的关联还没有调查，包括不同类群的分析将提供强有力的支持，了解协会。在这里，我进行了广泛的文献综述，并收集了已发表的关于TRPA 1的热阈值和三个生理参数的数据：实验自愿最大值（EVM），这是诱导热回避行为时的体温;临界热最大值（CTmax），这是一个温度点，超过这个温度，生物体就会丧失能力;以及现场记录的平均体温（T-mean）。然后，我检查了TRPA 1的热阈值与三个生理参数之间的关系。由于亲缘关系密切的物种往往表现出相似的性状值之间的物种，我进行了回归分析，占物种之间的系统发育距离。这项研究支持了先前的研究，证实了TRPA 1的热阈值与动物逃离热源的体温（在此表示为EVM）基本相关。然而，TRPA 1的热阈值与CTmax和T-mean的相关性在统计学上不显著。结果表明，虽然TRPA 1的热阈值是进化不稳定的，它与EVM的协会是高度保守的不同的陆地外温动物。因此，TRPA 1的热阈值可以作为一个有用的参数来评估物种对热胁迫的脆弱性，特别是在最近的气候变暖的情况下。
Temperature is an essential environmental factor that controls an organism's performances. As ectothermic animals largely rely on external heat sources for adjusting their body temperature, thermal perception is a primary process of behavioral thermoregulation. Transient receptor potential ankyrin 1 (TRPA1) is a heat sensitive ion channel in most non-mammalian species, and its heat activation has been suggested to induce heat avoidance behaviors in ectothermic animals. However, associations between TRPA1 and ecologically relevant temperatures have not been investigated, and the analyses including diverse taxa will provide robust support for understanding the associations. Here, I conducted extensive literature review, and assembled published data on thermal threshold of TRPA1 and three physiological parameters: the experimental voluntary maximum (EVM), which is body temperatures when heat avoidance behaviors are induced; the critical thermal maximum (CTmax), which is a point in temperature beyond which an organism becomes incapacitated; and average body temperature (T-mean) recorded in the field. Then, I examined the relationships between thermal threshold of TRPA1 and each of the three physiological parameters. As phylogenetically closely related species tend to show similar trait values among species, I conducted the regression analyses by accounting for phylogenetic distances among species. This study supports previous research by affirming that thermal threshold of TRPA1 is substantially correlated with body temperature that the animals escaped from the heat source, represented here as EVM. Nevertheless, thermal threshold of TRPA1 showed a statistically insignificant correlation with CTmax and T-mean. The results suggest that although thermal threshold of TRPA1 is evolutionarily labile, its associations with EVM is highly conserved among diverse terrestrial ectotherms. Therefore, thermal threshold of TRPA1 could be a useful parameter to evaluate species vulnerability to thermal stress particularly in the recent climate warming scenario.