Quantifying effects of plaque structure and material properties on stress distributions in human atherosclerotic plaques using 3D FSI models
Quantifying effects of plaque structure and material properties on stress distributions in human atherosclerotic plaques using 3D FSI models
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DOI：
10.1115/1.2073668
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发表时间：
2005-12-01
影响因子：
1.7
通讯作者：
Yuan, C
中科院分区：
文献类型：
--
作者：
Tang, DL;Yang, C;Yuan, C
背景：动脉粥样硬化斑块可能会在没有警告的情况下破裂并导致急性心血管综合征，例如心脏病发作和中风。迫切需要无创评估斑块脆弱性并预测可能的斑块破裂的方法。方法：引入基于MRI的具有多成分斑块结构和流固相互作用的人体动脉粥样硬化三维非定常模型，对人体动脉粥样硬化斑块进行力学分析。结果：关键部位（例如斑块中的薄帽）的应力变化可能比其他正常部位高 300%。大的钙化块显着改变应力/应变分布。斑块组件的刚度变化（减少 50% 或增加 100%）可能会影响最大应力值 20-50%。斑块帽腐蚀几乎不会导致帽处最大应力水平发生变化，但会导致最大应变值增加 50%。结论：通过广泛的计算案例研究和参数评估，量化了动脉粥样硬化斑块结构、帽厚度和侵蚀、材料特性以及脉动压力条件对斑块中应力/应变分布的影响。计算力学分析在提高斑块脆弱性评估的准确性方面具有良好的潜力。
Background: Atherosclerotic plaques may rupture without warning and cause acute cardiovascular syndromes such as heart attack and stroke. Methods to assess plaque vulnerability noninvasively and predict possible plaque rupture are urgently needed. Method: MRI-based three-dimensional unsteady models for human atherosclerotic with multi-component plaque structure and fluid-structure interactions are introduced to perform mechanical analysis for human atherosclerotic plaques. Results: Stress variations on critical sites such as a thin cap in the plaque can be 300% higher than that at other normal sites. Large calcification block considerably changes stress/strain distributions. Stiffness variations of plaque components (50% reduction or 100% increase) may affect maximal stress values by 20-50%. Plaque cap erosion causes almost no change on maximal stress level at the cap, but leads to 50% increase in maximal strain value. Conclusions: Effects caused by atherosclerotic plaque structure, cap thickness and erosion, material properties, and pulsating pressure conditions on stress/strain distributions in the plaque are quantified by extensive computational case studies and parameter evaluations. Computational mechanical analysis has good potential to improve accuracy of plaque vulnerability assessment.