Oxidation of low density lipoproteins by myeloperoxidase at the surface of endothelial cells: an additional mechanism to subendothelium oxidation
Oxidation of low density lipoproteins by myeloperoxidase at the surface of endothelial cells: an additional mechanism to subendothelium oxidation
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DOI：
10.1016/j.bbrc.2004.10.049
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发表时间：
2004-12-10
影响因子：
3.1
通讯作者：
Remacle, C
中科院分区：
文献类型：
--
作者：
Boudjeltia, KZ;Moguilevsky, N;Remacle, C
目前的动脉粥样硬化范例表明，低密度脂蛋白（LDL）被困在血管壁的内皮下空间中，在那里它们被氧化。髓过氧化物酶（MPO）在氧化损伤中发挥着关键作用。我们认为，髓过氧化物酶（Mox-LDL）对 LDL 的氧化可能发生在内皮细胞表面，而不仅限于内皮下空间。内皮细胞构成的三联体、循环LDL和MPO密切相互作用，构成了Mox-LDL发生的协同机制。 (C) 2004 Elsevier Inc. 保留所有权利。
The present paradigm of atherogenesis proposes that low density lipoproteins (LDL) are trapped in subendothelial space of the vascular wall where they are oxidized. Myeloperoxidase (MPO) plays a key role in oxidative damage. We propose that LDL oxidation by myeloperoxidase (Mox-LDL) could occur at the surface of the endothelial cells and not restricted to the subendothelial space. The triad constituted by endothelial cells, circulating LDL and MPO in close interaction, constitutes a synergic mechanism for the genesis of Mox-LDL. (C) 2004 Elsevier Inc. All rights reserved.