Obesity, mortality, and life years lost associated with breast cancer in nonsmoking US Women, National Health Interview Survey, 1997-2000.
Obesity, mortality, and life years lost associated with breast cancer in nonsmoking US Women, National Health Interview Survey, 1997-2000.
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DOI：
10.5888/pcd10.130112
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发表时间：
2013-11-14
影响因子：
5.5
通讯作者：
Colditz GA
中科院分区：
文献类型：
--
作者：
Chang SH;Pollack LM;Colditz GA
肥胖和乳腺癌之间的关系已经得到了广泛的研究。然而，肥胖症和乳腺癌如何相互作用影响美国女性的死亡率和预期寿命还没有得到很好的研究。我们使用了1997-2000年全国健康访谈调查的数据。我们的样本包括不吸烟、未怀孕的妇女，她们报告的体重指数至少为18.5公斤/平方米，在调查时除乳腺癌外没有其他癌症。使用Gamma Frailty和Gompertz基线的生存模型，根据肥胖状况和年龄估计与乳腺癌相关的总死亡率和预计寿命损失的相对风险。乳腺癌会增加死亡风险，这取决于肥胖的程度，寿命减少1到12年，取决于种族、年龄和肥胖状况。死亡的相对风险随着肥胖程度的增加而增加。据预测，在所有种族中，50岁以下的肥胖女性寿命损失最多；白人和黑人以外的种族损失最多(11.9岁)，其次是白人(9.8岁)和黑人(9.2岁)。与乳腺癌相关的寿命损失年数，肥胖程度较高的女性、50岁以下的女性和70岁或以上的女性比50岁至69岁的女性更显著。公共卫生倡议应更多地强调预防和控制这些目标人群的肥胖。
The relationship between obesity and breast cancer has been extensively investigated. However, how obesity and breast cancer interplay to affect mortality and life expectancy of women in the United States has not been well studied. We used data from the National Health Interview Survey, 1997–2000. Our sample included nonsmoking, nonpregnant women who reported a body mass index of at least 18.5 kg/m2 and no cancer other than breast cancer at the time of the survey. A survival model with Gamma frailty and Gompertz baseline was used to estimate relative risks of total mortality and project life years lost associated with breast cancer by obesity status and age. Breast cancer increased risk of mortality depending on degree of obesity and decreased life years by 1 to 12 years depending on race, age, and obesity status. Relative risks for death increased with degree of obesity. Obese women under age 50 across all racial groups were predicted to lose the most life years; racial groups other than whites and blacks lost the most life years (11.9 y), followed by whites (9.8 y) and blacks (9.2 y). The number of life years lost associated with breast cancer was more marked for more obese than for less obese women and for women under age 50 and women aged 70 or older than for women aged 50 through 69. Public health initiatives should put more emphasis on the prevention and control of obesity for these target populations.
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影响因子：
158.5
作者：
Calle, EE;Thun, MJ;Heath, CW
通讯作者：
Heath, CW
影响因子：
4.5
作者：
Aragón TJ;Lichtensztajn DY;Katcher BS;Reiter R;Katz MH
通讯作者：
Katz MH
DOI：
10.1111/j.1467-789x.2004.00142.x
发表时间：
2004-08-01
期刊：
Obesity reviews : an official journal of the International Association for the Study of Obesity
影响因子：
--
作者：
Rose, D P;Komninou, D;Stephenson, G D
通讯作者：
Stephenson, G D
从癌症中丧生（YLL）是人口负担的重要衡量标准，在分配研究基金时应考虑。
影响因子：
8.8
作者：
Burnet, NG;Jefferies, SJ;Benson, RJ;Hunt, DP;Treasure, FP
通讯作者：
Treasure, FP
影响因子：
2.1
作者：
Missov, Trifon I.
通讯作者：
Missov, Trifon I.