Amniotic membrane transplantation in refractory neurotrophic corneal ulcers - A randomized, controlled clinical trial
Amniotic membrane transplantation in refractory neurotrophic corneal ulcers - A randomized, controlled clinical trial
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DOI：
10.1097/01.ico.0000153102.19776.80
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发表时间：
2005-08-01
期刊：
影响因子：
2.8
通讯作者：
Vajpayee, RB
中科院分区：
文献类型：
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作者：
Khokhar, S;Natung, T;Vajpayee, RB
目的：本研究旨在比较和评价羊膜移植与常规治疗方法（泪膜修补术和绷带接触镜）治疗难治性神经营养性角膜溃疡的疗效。方法：选取30例难治性神经营养性角膜溃疡患者（女14例，男16例）30只眼，随机分为1组（n = 15）和2组（n = 15）， 1组采用常规治疗方法（11例），2组采用羊膜移植。评估的结果参数是上皮化时间、角膜溃疡愈合时间和最佳矫正视力的改善。结果：本组患者平均年龄为37±14.71岁。随访3个月时，1组15例患者中有10例（66.67%）上皮完全化并愈合，2组15例患者中有11例（73.33%）上皮完全化并愈合（P < 0.05）。两组完全上皮化的中位时间均为21天。两组患者的最佳矫正视力均有改善。结论：羊膜移植和常规治疗（缝合术或绷带接触镜）是治疗难治性神经营养性角膜溃疡的有效方法。
Purpose: This study was designed to compare and evaluate the efficacy of amniotic membrane transplantation with the conventional management (tarsorrhaphy and bandage contact lens) in eyes with refractory neurotrophic corneal ulcers.Methods: Thirty eyes of 30 patients (14 females and 16 males) with neurotrophic corneal ulcers refractory to medical management were included and divided randomly into group 1 (n = 15), who received conventional management with a tarsorrhaphy (n = 11) or bandage contact lens (n = 4), and group 2 (n = 15), who underwent Amniotic Membrane Transplantation. The outcome parameters evaluated were epithelialization time, duration of healing of corneal ulcers, and improvement in best corrected visual acuity.Results: The mean age in our study was 37 +/- 14.71 years. At the end of 3 months follow-up, 10 of 15 patients (66.67%) in group 1 showed complete epithelialization and subsequent healing and 11f 15 patients (73.33%) in group 2 showed complete epithelialization and healing (P > 0.05). The median time for complete epithelialization was 21 days in both groups. Both groups showed an improvement in the best-corrected visual acuity.Conclusions: Both amniotic membrane transplantation and conventional management (tarsorrhaphy or bandage contact lens) are effective treatment modalities for refractory neurotrophic corneal ulcers.