The TWIN-E Project in Emotional Wellbeing: Study Protocol and Preliminary Heritability Results Across Four MRI and DTI Measures
The TWIN-E Project in Emotional Wellbeing: Study Protocol and Preliminary Heritability Results Across Four MRI and DTI Measures
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DOI：
10.1017/thg.2012.12
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发表时间：
2012-06-01
影响因子：
0.9
通讯作者：
Williams, Leanne M.
中科院分区：
文献类型：
--
作者：
Gatt, Justine M.;Korgaonkar, Mayuresh S.;Williams, Leanne M.
尽管神经遗传学在心理健康方面取得了重大进展，但风险和弹性的潜在内表型标记物的识别和验证仍有待确认。TWIN-E研究（使用情绪综合神经科学的双胞胎健康研究）旨在通过在大型成人双胞胎队列中测试这些指标的遗传性，临床可接受性和可靠性，验证认知，大脑和自主神经指标中心理健康的内在表型标志物。也将确定特定的基因和环境机制，温和的内表型-表型标记和幸福的最终结果之间的前瞻性联系。TWIN-E是一项国家前瞻性研究，分为三个阶段：I）在线问卷和认知任务电池的基线测试，以及EEG，MRI和自主测试; II）在线评估的12个月随访测试;和III）大脑训练的随机对照试验。最低目标数量包括1，500名男性/女性双胞胎（18-65岁）用于在线评估（第一阶段和第二阶段），300名双胞胎用于EEG测试部分，244名双胞胎用于MRI测试部分。对于第三阶段，每对双胞胎将被随机分配到治疗组或等待名单对照组，以测试大脑训练对30天内心理健康的影响，并确认基因环境和内在表型对治疗反应的贡献。提供了MRI亚组（n = 142）前50%的灰质体积、厚度和表面积测量值以及白色物质弥散张量成像分数各向异性的初步遗传性结果。
Despite the significant advancements being made in the neurogenetics for mental health, the identification and validation of potential endophenotype markers of risk and resilience remain to be confirmed. The TWIN-E study (The Twin study in Wellbeing using Integrative Neuroscience of Emotion) aims to validate endophenotype markers of mental health across cognitive, brain, and autonomic measures by testing the heritability, clinical plausibility, and reliability of each of these measures in a large adult twin cohort. The specific gene and environmental mechanisms that moderate prospective links between endophenotype-phenotype markers and the final outcome of wellbeing will also be identified. TWIN-E is a national prospective study with three phases: I) baseline testing on a battery of online questionnaires and cognitive tasks, and EEG, MRI, and autonomic testing; II) 12-month follow-up testing on the online assessments; and III) randomized controlled trial of brain training. Minimum target numbers include 1,500 male/female twins (18-65 years) for the online assessments (Phase I and II), 300 twins for the EEG testing component, and 244 twins for the MRI testing component. For Phase III, each twin out of the pair will be randomized to either the treatment or waitlist control group to test the effects of brain training on mental health over a 30-day period, and to confirm the gene environment and endophenotype contributions to treatment response. Preliminary heritability results are provided for the first 50% of the MRI subgroup (n = 142) for the grey matter volume, thickness, and surface area measures, and white matter diffuse tensor imaging fractional anisotropy.