Optical imaging of plastic changes induced by fear conditioning in the auditory cortex
Optical imaging of plastic changes induced by fear conditioning in the auditory cortex
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DOI：
10.1007/s11571-011-9173-x
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发表时间：
2011-08
影响因子：
3.7
通讯作者：
Yoshinori Ide;Takashi Miyazaki;J. Lauwereyns;Guy Sandner;M. Tsukada;T. Aihara
中科院分区：
文献类型：
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作者：
Yoshinori Ide;Takashi Miyazaki;J. Lauwereyns;Guy Sandner;M. Tsukada;T. Aihara
用电压敏感染料RH795光记录法研究了恐惧条件化（即声刺激与电刺激相结合）引起的听觉皮层可塑性变化。为了研究联想学习的效果，在正常和假条件化之前和之后，记录了听觉皮层对CS（12 kHz纯音）和非CS（4，8，16 kHz纯音）的光信号。结果表明，条件反射后，仅条件反射组对CS的反应面积增大。此外，条件化后CS听觉反应的上升时间常数显著降低，相对峰值和衰减时间常数显著增加。本研究介绍了一种光学方法的调查恐惧条件反射，代表性的可塑性，和胆碱能系统。这些发现综合在一个模型的突触机制，皮层可塑性的基础。
The plastic changes in the auditory cortex induced by a fear conditioning, through pairing a sound (CS) with an electric foot-shock (US), were investigated using an optical recording method with voltage sensitive dye, RH795. In order to investigate the effects of association learning, optical signals in the auditory cortex in response to CS (12 kHz pure tone) and non-CS (4, 8, 16 kHz pure tone) were recorded before and after normal and sham conditioning. As a result, the response area to CS enlarged only in the conditioning group after the conditioning. Additionally, the rise time constant of the auditory response to CS significantly decreased and the relative peak value and the decay time constant of the auditory response to CS significantly increased after the conditioning. This study introduces an optical approach to the investigation of fear conditioning, representational plasticity, and the cholinergic system. The findings are synthesized in a model of the synaptic mechanisms that underlie cortical plasticity.