Benzodiazepines attenuate single unit activity in the locus coeruleus.
Benzodiazepines attenuate single unit activity in the locus coeruleus.
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苯二氮卓类药物会减弱蓝斑的单个单位活性。
DOI：
10.1016/0024-3205(80)90389-6
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发表时间：
1980
期刊：
影响因子：
6.1
通讯作者：
RedmondJr,DE
中科院分区：
文献类型：
--
作者：
Grant,SJ;Huang,YH;RedmondJr,DE
几类抗焦虑化合物具有降低去甲肾上腺素能神经元的放电或减弱去甲肾上腺素能活性的突触后效应的共同作用。为了确定最广泛使用的抗焦虑药苯二氮卓类是否也会降低去甲肾上腺素能活性，对麻醉大鼠急性静脉注射地西泮（0.1-2.0 mg/kg）和利氮卓（0.5-4.0 mg/kg），同时记录主去甲肾上腺素能核（蓝斑）中单个神经元的自发活动。地西泮和利氮卓在相对低剂量时可降低蓝斑的自发单位活动。这种对去甲肾上腺素能系统的净效应与几类非苯二氮卓类抗焦虑药的作用一致，并且与去甲肾上腺素能系统参与焦虑的神经机制一致。
Several classes of anxiolytic compounds have the common effect of decreasing the firing of noradrenergic neurons or attenuating the post- synaptic effects of noradrenergic activity. In order to determine whether the benzodiazepines, the most widely used anxiolytics, also decrease noradrenergic activity, the effect of acute intravenous injections of diazepam (0.1–2.0 mg/kg) and chlordiazepoxide (0.5–4.0 mg/kg) were administered to anesthetized rats while spontaneous activity of single neurons in the principal noradrenergic nucleus, the locus coeruleus, was recorded. Diazepam and chlordiazepoxide decreased spontaneous single unit activity in the locus coeruleus at relatively low doses. This net effect on noradrenergic systems is consistent with the actions of several classes of nonbenzodiazepine anxiolytics, and with the involvement of noradrenergic systems in the neural mechanisms of anxiety.