VARIATION IN THE SEQUENCE AND MODIFICATION STATE OF THE HUMAN INSULIN GENE FLANKING REGIONS
VARIATION IN THE SEQUENCE AND MODIFICATION STATE OF THE HUMAN INSULIN GENE FLANKING REGIONS
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DOI：
10.1093/nar/10.7.2225
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发表时间：
1982-01-01
影响因子：
14.9
通讯作者：
PETER, S
中科院分区：
文献类型：
--
作者：
ULLRICH, A;DULL, TJ;PETER, S
报道了htisan胰岛素基因上游高重复序列区域的核苷酸序列。这一区域的长度因种群中的等位基因而异，并且似乎以孟德尔式的方式稳定地传递给下一代。该序列的长度与两种类型的糖尿病之间没有明显的相关性。我们观察到人类胰岛素基因下游的bgll识别位点的切割能力的变化，这可能是由于可变的核苷酸修饰所致。这种假定的修改状态似乎不是遗传的，并且在个体内的组织之间以及给定组织的个体之间有所不同。给定组织DNA样本中的两个等位基因都被修改到相同的程度。
The nucleotide sequence of a highly repetitive sequence region upstream from the htisan insulin gene is reported. The length of this region varies between alleles in the population, and appears to be staoly transmitted to the next generation in a Mendelian fashion. There is no significant correlation between the length of this sequence and two types of diabetes mellitus. We observe variation in the cleavability of a Bgll recognition site downstream from the human insulin gene, which is probably due to variable nucleotide modification. This presumed modification state appears not to be inherited, and varies between tissues within an individual and between individuals for a given tissue. Both alleles in a given tissue DNA sample are modified to the same extent.