Tunable conformation and stability of amidourea-based hydrogen-bonded heteroduplexes
Tunable conformation and stability of amidourea-based hydrogen-bonded heteroduplexes
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基于氨基脲的氢键异源双链体的可调构象和稳定性
DOI：
10.1016/j.tet.2012.08.092
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发表时间：
2012-11-11
期刊：
影响因子：
2.1
通讯作者：
Chen, Chuan-Feng
中科院分区：
文献类型：
--
作者：
Chu, Wei-Jun;Chen, Chuan-Feng
利用酰胺衍生物构建了一类多氢键异源双链体，并对其结构和缔合稳定性进行了研究。虽然酰胺基衍生物具有不同的间隔区或末端，但它们可以调整其构象以获得最佳结合模块。因此，所有的异源双链体通过基于酰胺基序的八个分子间分叉氢键采用相似的氢键模式。此外，还发现异源双链体的缔合稳定性可以通过改变单体的间隔基或末端来很好地调节。(C)2012爱思唯尔有限公司保留所有权利。
A class of multiply hydrogen-bonded heteroduplexes were constructed from readily available amidourea derivatives, and their structures and association stabilities were investigated. Although the amidourea derivatives possessed different spacers or termini, they could adjust their conformations to achieve an optimal binding module. Consequently, all the heteroduplexes adopted similar hydrogen-bonding patterns through eight intermolecular bifurcated hydrogen bonds based on the amidourea motif. Moreover, it was also found that the association stabilities of the heteroduplexes could be well tuned by varying the spacers or termini of the monomers. (C) 2012 Elsevier Ltd. All rights reserved.