Laser assisted microfluidic membrane evaporator for sample crystallization separation
Laser assisted microfluidic membrane evaporator for sample crystallization separation
复制标题
用于样品结晶分离的激光辅助微流控膜蒸发器
DOI：
10.1016/j.seppur.2020.116817
复制
发表时间：
2020-07
影响因子：
8.6
通讯作者：
Li Shuzhe
中科院分区：
文献类型：
--
作者：
He Xuefeng;Chen Rong;Zhu Xun;Liao Qiang;Li Shuzhe
用于样品结晶分离的微流控器件在各种片上分析测试场景中起着至关重要的作用。基于蒸发的微流控结晶技术是芯片上样品富集和结晶分离的重要方法之一。然而，封闭芯片器件中的溶剂蒸发过程受到蒸气传输差、界面行为不稳定和蒸发速率低的严重限制。针对这些问题，本文设计了一种用于快速连续流动样品结晶分离的微流控膜蒸发器。在该设计中，激光诱导加热效应被用来触发溶剂的蒸发，透气疏水聚四氟乙烯膜被用来稳定的气液界面，并提供蒸发过程中的蒸汽通道。研究了激光功率、溶液流速和样品浓度对结晶分离性能的影响。结果表明，所设计的微流控膜蒸发器在不同操作条件下均具有良好的结晶分离性能，可进一步应用于不同类型的微流控系统和平台，用于片上分析测试。
Microfluidic devices for sample crystallization separation plays crucially important role in various on-chip analytical and testing scenes. Evaporation-based microfluidic crystallization technology is one of the most important methods for on-chip sample enrichment and crystallization separation. However, the solvent evaporation process in closed chip device is severely limited by poor vapor transportation, unstable interfacial behaviors and low evaporation rate. Aiming to address these issues, here we designed a microfluidic membrane evaporator for fast continuous flow sample crystallization separation. In this design, laser induced heating effect was employed to trigger the evaporation of the solvent, gas-permeable hydrophobic polytetrafluoroethylene membrane was used to stabilize the gas-liquid interface and provide vapor pathways during the evaporation process. Effects of laser power, solution flow rate and sample concentration on the crystallization separation performance was investigated. Results indicates the designed microfluidic membrane evaporator has good crystallization separation performance under different operation conditions, which can be further applied to different types of microfluidic systems and platforms for on-chip analysis and testing.