Omega-3 fatty acids, endogenous prostaglandins, and blood pressure regulation in humans.
Omega-3 fatty acids, endogenous prostaglandins, and blood pressure regulation in humans.
复制标题
Omega-3 脂肪酸、内源性前列腺素和人体血压调节。
DOI：
10.1111/j.1753-4887.1989.tb02754.x
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发表时间：
1989
影响因子：
6.1
通讯作者：
Knapp,HR
中科院分区：
文献类型：
--
作者：
Knapp,HR
据报道，Omega-3脂肪酸补充剂对人体有降压作用，有人认为这种作用是由于前列腺素合成的改变。然而，这种效果的发现并不一致，而且对文献的解释也因研究设计的问题而混淆。流行病学数据经常被引用，表明大量食用鱼类的人群血压较低，但从原始数据来看，这种影响也不太清楚。这篇综述介绍了omega-3脂肪酸与血压之间关系的人群研究，血压研究中涉及的问题，以及在志愿者中使用omega-3补充剂降低血压和血管反应性的研究。本文还总结了omega-3脂肪酸和内源性前列腺素生成的数据，并对膳食omega-3脂肪酸和血管控制的研究进行了解释。最近的研究提出了一些有争议的观点，结论是药理学剂量的omega-3脂肪酸可以降低人类的血压，但可能不是通过改变前列腺素的产生直接起作用的。
Omega-3 fatty acid supplements have been reported to have hypotensive properties in humans, and it has been suggested that this effect is due to altered prostaglandin synthesis. However, such effects are inconsistently found, and interpretation of the literature is confounded by problems with study design. Epidemiologic data are often quoted as showing lower blood pressure in populations that eat large amounts of fish, but this effect also is less clear from the primary data. This review presents population studies of the relationship between consumption of omega-3 fatty acids and blood pressure, problems involved in studying blood pressure, and the studies of lowering blood pressure and vascular reactivity with omega-3 supplements in volunteers. Data on omega-3 fatty acids and endogenous production of prostaglandins are also summarized, with interpretation of investigations of dietary omega-3 fatty acids and vascular control. Recent work addressing a number of controversial points is presented, with the conclusion that pharmacologic doses of omega-3 fatty acids can lower blood pressure in humans but probably do not do so directly via altered production of prostaglandins.