Food restriction and leptin impact brain reward circuitry in lean and obese Zucker rats
Food restriction and leptin impact brain reward circuitry in lean and obese Zucker rats
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DOI：
10.1016/j.bbr.2004.05.021
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发表时间：
2004-12-06
影响因子：
2.7
通讯作者：
Shizgal, P
中科院分区：
文献类型：
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作者：
Fulton, S;Richard, D;Shizgal, P
电刺激外侧下丘脑（LH）某些部位所产生的奖赏效应可通过限食和减轻体重而增强。中枢瘦素和胰岛素给药可以抑制刺激的奖励作用。为了确定是否有额外的外周信号介导体重减轻对大脑奖励回路的影响，我们评估了肥胖Zucker大鼠在食物限制后LH自我刺激的变化，该大鼠对循环瘦素和胰岛素产生了抵抗。此外，我们研究了急性食物剥夺和瘦素管理对瘦和肥胖Zucker大鼠LH自我刺激的影响。获得的脑刺激奖励的数量是在一系列LH刺激频率上测量的，这些频率将奖励率从零提高到渐近水平。限制减少频率阈值在一个子集的瘦和肥胖的大鼠，而BSR是不变的急性食物剥夺。尽管瘦素信号传导受损，但脑室内瘦素（4 μ g）增加了大多数瘦和肥胖大鼠的阈值，其中奖励效应对限制敏感。这些结果表明，肥胖Zucker大鼠的大脑奖励回路对体重减轻和瘦素敏感。(C)2004 Elsevier B.V.保留所有权利。
The rewarding effect produced by electrically stimulating certain sites in the lateral hypothalamus (LH) can be potentiated by food restriction and body weight loss in lean rats. Central leptin and insulin administration can suppress the rewarding impact of the stimulation. To determine whether there are additional peripheral signals that mediate the effect of weight loss on brain reward circuitry, we assessed changes in LH-self-stimulation following food restriction in the obese Zucker rat which develops resistance to circulating leptin and insulin. In addition, we examined the impact of acute food deprivation and leptin administration on LH self-stimulation in lean and obese Zucker rats. The number of brain stimulation rewards earned was measured over a range of LH stimulation frequencies that drove reward rates from zero to asymptotic levels. Restriction reduced frequency thresholds in a subset of lean and obese rats, whereas BSR was unaltered by acute food deprivation. Despite impairment in leptin signaling, intraventricular leptin (4 mug) increased thresholds in most lean and obese rats in which the rewarding effect was sensitive to restriction. These results show that brain reward circuitry in the obese Zucker rat is sensitive to weight loss and leptin. (C) 2004 Elsevier B.V. All rights reserved.