Postnatal handling reduces emotionality ratings and accelerates two-way active avoidance in female rats
Postnatal handling reduces emotionality ratings and accelerates two-way active avoidance in female rats
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DOI：
10.1016/0031-9384(94)00308-r
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发表时间：
1995-05
影响因子：
2.9
通讯作者：
J. F. Núñez;P. Ferré;Ernesto García;R. M. Escorihuela;A. Fernández-Teruel;A. Tobeña
中科院分区：
文献类型：
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作者：
J. F. Núñez;P. Ferré;Ernesto García;R. M. Escorihuela;A. Fernández-Teruel;A. Tobeña
本研究评估了出生后处理（PH;在生命的前21天每天给药）是否可以减少自发或条件性恐惧相关行为任务中的焦虑或情绪反应。为了这个目的，控制nonhandled和postnatally处理雌性大鼠提交了三个不同的行为测试：情绪性评级（ER），其次是一个升高的十字迷宫测试的焦虑在一个实验中，和收购的双向主动（梭箱）避免在两个不同的训练条件下，在一个单独的实验。PH治疗的显着效果出现在三个测试的情况下，清楚地表明一个重要的和持久的减少PH治疗的大鼠的情绪/焦虑。特别感兴趣的是梭箱训练的结果：通过缩短条件刺激（CS）和试验间隔（ITI）的持续时间，如预期的那样，回避获得受损，但PH的改善效果更为显着。结果进行了讨论，在以前的研究报告有争议的结果在相同（或类似）的测试情况。
The present study evaluated whether postnatal handling (PH; administered daily during the first 21 days of life) could reduce anxiety or emotional reactivity in tasks of either spontaneous or conditioned fear-related behavior. To this purpose control nonhandled and postnatally handled female rats were submitted to three different behavioral tests: an emotionality rating (ER) followed by an elevated plus-maze test of anxiety in one experiment, and an acquisition of two-way active (shuttlebox) avoidance under two different training conditions in a separate experiment. Significant effects of PH treatment appeared in the three testing situations, clearly indicating an important and enduring reduction of emotionality/anxiety in PH-treated rats. Of especial interest were the results of shuttlebox training: by shortening the conditioned stimulus (CS) and the intertrial interval (ITI) duration, avoidance acquisition was impaired as expected but the improving effects of PH were even more marked. The results are discussed in relation to previous studies reporting controversial results in the same (or similar) testing situations.