Wernicke's encephalopathy in uremia
Wernicke's encephalopathy in uremia
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尿毒症韦尼克脑病
DOI：
10.1212/wnl.22.12.1293
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发表时间：
1972
期刊：
影响因子：
9.9
通讯作者：
A. Faris
中科院分区：
文献类型：
--
作者：
A. Faris
中枢神经系统功能障碍是肾衰竭的已知和有充分记录的并发症。然而，一个一致的形态学或生理学的对应临床图片尚未明确建立。最近描述的S ~ hneck ~，~所注意到的形态学变化可能归因于现代尿毒症治疗中使用的特异性治疗剂。尿毒症患者周围神经的结构和生理改变已经有很好的记录。[6]我们最近遇到了一个肾功能不全的病人，他的尸检发现他有韦尼克脑病的特征性变化。据我们所知，洛佩斯和C ~ l l in s曾描述过一个类似的病例;该患者除了发现韦尼克脑病外，还有脑桥中央髓鞘溶解的特征性病变。
Disturbance of central nervous system function is a known and well-documented complication of renal failure. However, a consistent morphologic’ or physiologic’ counterpart to the clinical picture has not been clearly established. The more recently described morphologic changes noted by S ~ h n e c k ~ , ~ may be ascribed t o specific therapeutic agents used in the modern treatment of uremia. Structural and physiologic alterations affecting the peripheral nerves in uremia have been well documented.’ ¶6 We have recently encountered a patient with renal insufficiency who, a t postmortem examination, was found to have changes characteristic of Wernicke’s encephalopathy. To our knowledge, one similar case has been described by Lopez and C ~ l l i n s ; ~ this patient, in addition to findings of Wernicke’s encephalopathy, had a lesion characteristic of central pontine myelinolysis.8