Oral Osteomicrobiology: The Role of Oral Microbiota in Alveolar Bone Homeostasis.
Oral Osteomicrobiology: The Role of Oral Microbiota in Alveolar Bone Homeostasis.
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口腔骨微生物学：口腔微生物群在牙槽骨稳态中的作用
DOI：
10.3389/fcimb.2021.751503
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发表时间：
2021
影响因子：
5.7
通讯作者：
Xu X
中科院分区：
文献类型：
--
作者：
Cheng X;Zhou X;Liu C;Xu X
骨微生物学是一个新的研究领域，其目的是探索微生物群在骨稳态中的作用。牙槽骨是上颌骨和下颌骨支撑牙齿的部分。现在很明显，与无特定病原体的小鼠相比，无菌小鼠中自然发生的牙槽骨丢失明显受到阻碍。近年来，口腔微生物群在调节宿主防御系统和牙槽骨稳态中的作用引起了越来越多的关注。此外，由于技术的进步，对口腔微生物群介导牙槽骨重塑过程的机制的理解正在快速进展。在这篇综述中，为了深入了解口腔微生物群在牙槽骨稳态中的作用，我们引入了“口腔骨微生物学”这一术语。我们讨论了生理和病理条件下口腔微生物群对牙槽骨发育和骨质流失的调节。我们还重点关注了口腔骨微生物学中涉及的信号通路，并讨论了骨免疫的桥接作用以及在此过程中的影响因素。最后，介绍了骨微生物学研究的关键技术。
Osteomicrobiology is a new research field in which the aim is to explore the role of microbiota in bone homeostasis. The alveolar bone is that part of the maxilla and mandible that supports the teeth. It is now evident that naturally occurring alveolar bone loss is considerably stunted in germ-free mice compared with specific-pathogen-free mice. Recently, the roles of oral microbiota in modulating host defense systems and alveolar bone homeostasis have attracted increasing attention. Moreover, the mechanistic understanding of oral microbiota in mediating alveolar bone remodeling processes is undergoing rapid progress due to the advancement in technology. In this review, to provide insight into the role of oral microbiota in alveolar bone homeostasis, we introduced the term “oral osteomicrobiology.” We discussed regulation of alveolar bone development and bone loss by oral microbiota under physiological and pathological conditions. We also focused on the signaling pathways involved in oral osteomicrobiology and discussed the bridging role of osteoimmunity and influencing factors in this process. Finally, the critical techniques for osteomicrobiological investigations were introduced.