Aberrant homing of mucosal T cells and extra-intestinal manifestations of inflammatory bowel disease
Aberrant homing of mucosal T cells and extra-intestinal manifestations of inflammatory bowel disease
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DOI：
10.1038/nri1784
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发表时间：
2006-03-01
影响因子：
100.3
通讯作者：
Eksteen, B
中科院分区：
文献类型：
--
作者：
Adams, DH;Eksteen, B
活动性炎症性肠病（IBD）通常与皮肤，眼睛和关节的同时炎症有关。肝脏中的炎症性疾病也可发生在IBD患者中，但似乎与肠道炎症无关。在这篇观点文章中，我们提出IBD的肝脏并发症是由长寿命的粘膜T细胞介导的，这些T细胞被招募到肝脏，以响应异常表达的内皮细胞粘附分子和趋化因子，这些粘附分子和趋化因子通常局限于肠道。类似的机制可以解释为什么某些疾病与位点特异性组织分布相关，并可能指向基于调节组织特异性淋巴细胞归巢的新治疗策略。
Active inflammatory bowel disease (IBD) is often associated with simultaneous inflammation in the skin, eyes and joints. Inflammatory disease in the liver can also occur in patients with IBD but seems to be independent of inflammation in the bowel. In this Opinion article, we propose that the hepatic complications of IBD are mediated by long-lived mucosal T cells that are recruited to the liver in response to aberrantly expressed endothelial-cell adhesion molecules and chemokines that are normally restricted to the gut. Similar mechanisms might explain why certain diseases are associated with site-specific tissue distributions and might point to new therapeutic strategies that are based on modulating tissue-specific lymphocyte homing.