Relationship between serum concentrations of interleukin-6 and tumor necrosis factor alpha in female Turkish subjects with normal and impaired glucose tolerance
Relationship between serum concentrations of interleukin-6 and tumor necrosis factor alpha in female Turkish subjects with normal and impaired glucose tolerance
复制标题
DOI：
10.1055/s-2006-924974
复制
发表时间：
2006-01-01
影响因子：
2.2
通讯作者：
Bagriaçik, N
中科院分区：
文献类型：
--
作者：
Konukoglu, D;Hatemi, H;Bagriaçik, N
为探讨葡萄糖对血清IL-6和肿瘤坏死因子α(TNFa)浓度的影响，测定了受试者在糖负荷2小时内的血清IL-6和肿瘤坏死因子-α(TNF-α)浓度。按WHO标准，26例女性(平均年龄60~10岁)糖耐量正常(NGT)，19例女性糖耐量减低(IGT)，平均年龄63.9岁。采用化学发光免疫分析法检测血清IL-6和TNF-α水平。IGT患者的空腹血清肿瘤坏死因子α水平高于NGT患者(p<；0.01)。血清IL-6和TNFa浓度在葡萄糖负荷过程中升高(每个比较，p<；0.01)。IGT患者血清肿瘤坏死因子α浓度升高幅度大于NGT患者(p<；0.01)。IGT组血清IL-6、TNF-α水平与胰岛素、血糖呈显著正相关(P<0.01)。糖耐量低减患者的血糖和细胞因子浓度之间存在显著的相关性(对于每个比较，p<；0.01)。NGT组和IGT组血清IL-6和TNFa水平也呈正相关(P均<0.01)。总而言之，高血糖与循环细胞因子浓度升高有关，空腹肿瘤坏死因子α浓度与糖耐量减低的关系似乎比IL-6更大。
Serum interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF alpha) concentrations were measured in subjects during two-hour glucose loading in order to investigate the effects of glucose on serum IL-6 and TNFa concentrations. Twenty-six female subjects (mean age 60 10 years) had normal glucose tolerance (NGT) and nineteen female subjects (mean age: 63 9 years) had impaired glucose tolerance (IGT) according to WHO criteria. Serum IL-6 and TNF alpha concentrations were measured by chemiluminescent immunometric assay. Subjects with IGT have higher fasting serum TNF alpha levels than subjects with NGT (p < 0.01). Serum IL-6 and TNFa concentrations were elevated during glucose loading (for each comparision, p < 0.01). The increase in serum TNF alpha concentrations in IGT was greater than in NGT (p < 0.01). Serum IL-6 and TNF alpha concentration significantly correlated with insulin and glucose in IGT group (for each comparision, p < 0.01). The correlation between serum glucose and cytokines concentrations was significant in IGT (for each comparision, p < 0.01). There was also a positive correlation between serum IL-6 and TNFa in NGT and IGT (for each comparision, p < 0.01). In conclusion, hyperglycemia is associated with increased circulating cytokine concentrations and fasting TNF alpha concentrations seem to be more associated with IGT than IL-6.