Doxycycline attenuated lung injury by its biological effect apart from its antimicrobial function
Doxycycline attenuated lung injury by its biological effect apart from its antimicrobial function
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DOI：
10.1016/j.pupt.2006.08.006
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发表时间：
2007-01-01
影响因子：
3.2
通讯作者：
Nakanishi, Yoichi
中科院分区：
文献类型：
--
作者：
Fujita, Masaki;Harada, Eiji;Nakanishi, Yoichi
Antibiotics can have a biological effect apart from their anti-bacterial effect. We hypothesized that doxycycline could attenuate acute lung injury through its biological effect. Lipopolysaccharide or doxycycline-resistant Streptococcus pneumoniae was administered intratracheally into mice with the co-administration of doxycycline. Thereafter, the lung pathology, intraalveolar inflammatory cells, bacterial number, and matrix metalloproteinases were investigated. Matrix metalloproteinases, neutrophil migration, and alveolar destruction were induced by lipopolysaccharide. Doxycycline was thus found to improve all of these symptoms. In addition, an inhibitor of matrix metalloproteinases, CGS27023A, attenuated lipopolysaccharide-induced lung injury. Doxycycline also attenuated the lung injury induced by doxycycline-resistant S. pneumoniae and improved the mortality rate although the bacterial number in the lung did not change. Our data indicated that doxycycline could attenuate acute lung injury through a biological effect that was different from its antibiotic effect. (C) 2006 Elsevier Ltd. All rights reserved.
