Evaluation of systemic levels of neutrophilic enzymes in patients with hypertension and chronic periodontitis.
Evaluation of systemic levels of neutrophilic enzymes in patients with hypertension and chronic periodontitis.
复制标题
高血压和慢性牙周炎患者中性粒细胞酶的全身水平评估。
DOI：
10.1902/jop.2013.130346
复制
发表时间：
2014
影响因子：
4.3
通讯作者：
G. Atilla
中科院分区：
文献类型：
--
作者：
Oya Türkoğlu;N. Barış;T. Tervahartiala;Ö. Şenarslan;T. Sorsa;G. Atilla
背景
炎症刺激中性粒细胞将酶释放到细胞外基质中。本研究的目的是探讨高血压合并慢性牙周炎（CP）患者血清中基质金属蛋白酶（MMP）-8、MMP-9、MMP组织抑制剂（TIMP）-1、髓过氧化物酶（MPO）和中性粒细胞弹性蛋白酶（NE）的水平。
方法
该研究共有 95 名患者。患者被分为三组：健康对照组（n = 29）、高血压控制组（n = 32）和高血压CP（n = 34）。记录牙周参数，并收集每位参与者的血清样本。通过酶联免疫吸附测定评估循环中血清 MMP-8、MMP-9、TIMP-1、MPO 和 NE 水平。
结果
高血压CP组血清MMP-8、MMP-9、NE水平显着高于健康对照组（P<0.05）。所有研究组的血清TIMP-1水平相似（P>0.05）。高血压合并脑瘫患者血清 MPO 水平显着高于健康对照和高血压对照（P <0.05）；健康对照者与高血压对照者血清MPO水平差异不显着（P>0.05）。各研究组间MMP-8/TIMP-1比值差异无统计学意义（P>0.05）。高血压合并脑瘫患者的MMP-9/TIMP-1比值显着高于健康对照者（P<0.05）。
结论
高血压和 CP 的存在对血清中性粒细胞酶水平（TIMP-1 除外）有相当大的影响。然而，这些酶的水平似乎不仅仅受到高血压的影响。包括仅患有 CP 的患者在内的进一步研究可能有助于阐明 CP 对高血压患者中这些酶的影响。
BACKGROUND
Inflammation stimulates neutrophils to release their enzymes into the extracellular matrix. The aim of the present study is to investigate the serum levels of matrix metalloproteinase (MMP)-8, MMP-9, tissue inhibitor of MMP (TIMP)-1, myeloperoxidase (MPO), and neutrophil elastase (NE) in patients with hypertension and chronic periodontitis (CP).
METHODS
A total of 95 patients were included in the study. Patients were categorized into three groups: healthy control (n = 29), hypertensive control (n = 32), and hypertensive CP (n = 34). Periodontal parameters were recorded, and serum samples were collected from each participant. Serum MMP-8, MMP-9, TIMP-1, MPO, and NE levels in circulation were assessed by enzyme-linked immunosorbent assay.
RESULTS
The hypertensive CP group had significantly higher serum MMP-8, MMP-9, and NE levels than the healthy control group (P <0.05). All study groups had similar serum TIMP-1 levels (P >0.05). Significantly higher serum MPO levels were detected in patients with hypertension and CP than healthy controls and hypertensive controls (P <0.05); however, the difference in serum MPO levels was not significant between the healthy controls and hypertensive controls (P >0.05). There was no significant difference in MMP-8/TIMP-1 ratio among the study groups (P >0.05). MMP-9/TIMP-1 ratio was significantly higher in patients with hypertension and CP than healthy controls (P <0.05).
CONCLUSIONS
The presence of hypertension along with CP has a considerable effect on serum neutrophilic enzyme levels, except TIMP-1. However, the levels of these enzymes do not seem to be affected by the presence of hypertension only. Further studies including patients who have only CP might help illuminate the effect of CP on these enzymes in patients with hypertension.
影响因子：
8.3
作者：
ALEXANDER, RW
通讯作者：
ALEXANDER, RW