New concepts in the pathogenesis of alcoholic liver disease.
New concepts in the pathogenesis of alcoholic liver disease.
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DOI：
10.1586/17474124.2.6.749
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发表时间：
2008-12-01
影响因子：
3.9
通讯作者：
Albano, Emanuele
中科院分区：
文献类型：
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作者：
Albano, Emanuele
酒精性肝病仍然是大多数发达国家死亡和残疾的重要原因，并正在成为发展中国家的主要疾病原因。现在越来越清楚的是，除了乙醛的形成外，酒精对肝脏的影响还包括氧化应激、甲硫氨酸代谢紊乱、内质网应激、炎症/免疫反应和脂肪因子失衡。本文将讨论酒精滥用导致肝脂肪变性和脂肪性肝炎的机制的最新发现，现在它有助于纤维化的进展。尽管仍不完整，但这些数据为酒精性肝病的多因素发病机制提供了新的线索，并为了解性别和遗传因素如何影响疾病进展开辟了新的可能性。
Alcoholic liver disease still represents an important cause for death and disability in most well-developed countries and is becoming a leading cause of disease in developing countries. It is now increasingly clear that, besides the formation of acetaldehyde, alcohol effects on the liver include oxidative stress, disturbances in methionine metabolism, endoplasmic reticulum stress, inflammatory/immune responses and adipokine imbalances. This article will discuss the most recent findings on the mechanisms by which alcohol abuse causes hepatic steatosis and steatohepatitis, and now it contributes to the progression of fibrosis. Although still incomplete, these data shed new light on the multifactorial pathogenesis of alcoholic liver disease and open new possibilities in the understanding of how gender and genetic factors can influence disease progression.