Prospects of IL-2 in Cancer Immunotherapy.

Prospects of IL-2 in Cancer Immunotherapy.
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DOI:
10.1155/2018/9056173
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发表时间:
2018
影响因子:
--
通讯作者:
Jamal MS
Jamal MS
中科院分区:
生物学3区
文献类型:
--
作者:
Choudhry H;Helmi N;Abdulaal WH;Zeyadi M;Zamzami MA;Wu W;Mahmoud MM;Warsi MK;Rasool M;Jamal MS

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IL-2 是一种强大的免疫生长因子,在维持 T 细胞反应中发挥着重要作用。 IL-2 在不丧失功能的情况下扩增 T 细胞的潜力使其在癌症免疫治疗中得到了早期应用。据报道,IL-2 可诱导癌症患者完全且持久的消退,但也有报道称免疫相关的不良反应 (irAE)。本综述讨论了 IL-2 在癌症免疫治疗中的前景。
IL-2 is a powerful immune growth factor and it plays important role in sustaining T cell response. The potential of IL-2 in expanding T cells without loss of functionality has led to its early use in cancer immunotherapy. IL-2 has been reported to induce complete and durable regressions in cancer patients but immune related adverse effects have been reported (irAE). The present review discusses the prospects of IL-2 in immunotherapy for cancer.
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