TSPAN1 inhibits metastasis of nasopharyngeal carcinoma via suppressing NF-kB signaling
TSPAN1 inhibits metastasis of nasopharyngeal carcinoma via suppressing NF-kB signaling
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DOI：
10.1038/s41417-023-00716-w
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发表时间：
2023-12
影响因子：
6.4
通讯作者：
Mingdian Wang;Huiting Li;Li-xia Peng;Yan Mei;Li-Sheng Zheng;Chang-Zhi Li;Dong-Fang Meng;Y. Lang;Liang Xu;Xing-Si Peng;Zhi-jie Liu;Detian Xie;Lingmin Guo;Mao-Guang Ma;Liu-Yan Ding;Bi-Jun Huang;Yun Cao;Chao-Nan Qian
中科院分区：
文献类型：
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作者：
Mingdian Wang;Huiting Li;Li-xia Peng;Yan Mei;Li-Sheng Zheng;Chang-Zhi Li;Dong-Fang Meng;Y. Lang;Liang Xu;Xing-Si Peng;Zhi-jie Liu;Detian Xie;Lingmin Guo;Mao-Guang Ma;Liu-Yan Ding;Bi-Jun Huang;Yun Cao;Chao-Nan Qian
鼻咽癌起源于鼻咽上皮细胞，是中国南部和东南亚地区常见的恶性肿瘤。尽管鼻咽癌对放疗和化疗敏感，但鼻咽癌转移仍是鼻咽癌患者的主要死亡原因。在这里，我们发现跨膜蛋白TSPAN1(TSPAN1)通过与IKBB蛋白相互作用而有效地抑制鼻咽癌细胞的体外迁移和侵袭，以及体内转移。此外，TSPAN1在防止过表达TSPAN1的鼻咽癌细胞中的NF-kB途径过度激活方面也是必不可少的。此外，TSPAN1表达降低与鼻咽癌转移和鼻咽癌患者预后不良有关。这些结果揭示了TSPAN1对鼻咽癌细胞中的NF-kB信号的抑制作用，从而阻止了鼻咽癌的转移。其治疗价值值得进一步研究。
Nasopharyngeal carcinoma (NPC) originates in the epithelial cells of the nasopharynx and is a common malignant tumor in southern China and Southeast Asia. Metastasis of NPC remains the main cause of death for NPC patients even though the tumor is sensitive to radiotherapy and chemotherapy. Here, we found that the transmembrane protein tetraspanin1 (TSPAN1) potently inhibited the in vitro migration and invasion, as well as, the in vivo metastasis of NPC cells via interacting with the IKBB protein. In addition, TSPAN1 was essential in preventing the overactivation of the NF-kB pathway in TSPAN1 overexpressing NPC cells. Furthermore, reduced TSPAN1 expression was associated with NPC metastasis and the poor prognosis of NPC patients. These results uncovered the suppressive role of TSPAN1 against NF-kB signaling in NPC cells for preventing NPC metastasis. Its therapeutic value warrants further investigation.