Invasive Pleomorphic Lobular Carcinoma of the Breast: Pathologic, Clinical, and Therapeutic Considerations
Invasive Pleomorphic Lobular Carcinoma of the Breast: Pathologic, Clinical, and Therapeutic Considerations
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DOI：
10.1016/j.clbc.2015.06.010
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发表时间：
2015-12-01
影响因子：
3.1
通讯作者：
Arnaout, Angel
中科院分区：
文献类型：
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作者：
Al-Baimani, Khalid;Bazzarelli, Amy;Arnaout, Angel
摘要多形性小叶癌是一种不常见的乳癌，也是浸润性小叶癌的一种亚型。它具有独特的组织病理学特征，转化为更具侵袭性的表型，预后不良。与经典的浸润性小叶癌不同，它可以失去雌激素和孕激素受体的表达，并显示HER-2/neu扩增。然而，多形性组织学是否能独立预测预后不良，或者其他已知的相关负性预后因素，如肿瘤较大、转移性疾病增加和多形性癌中常见的相关不良分子亚型是否能解释预后不良，仍有待确定。在此，我们对多形性小叶癌独特的病理和临床特征进行了最新的回顾，以指导患有这种癌症亚型的妇女的治疗。(C)2015 Elsevier Inc. All rights reserved.
Pleomorphic lobular carcinoma is an uncommon form of breast cancer and a subtype of invasive lobular carcinoma. It has unique histopathologic features that translate to a more aggressive phenotype with an associated poor prognosis. Unlike classical invasive lobular carcinoma, it can lose estrogen and progesterone receptor expression and demonstrate HER-2/neu amplification. It remains to be determined, however, whether the pleomorphic histology independently predicts a worse outcome or whether other known associated negative prognostic factors such as larger tumor size, increased metastatic disease, and associated worse molecular subtypes commonly present in pleomorphic carcinoma account for the poor prognosis. Here we present an updated review of the unique pathologic and clinical features of pleomorphic lobular carcinoma needed to guide management for women with this subtype of cancer. (C) 2015 Elsevier Inc. All rights reserved.